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Compressible mixture, compressed pharmaceutical compositions, and method of preparation thereof

  • US 20060263429A1
  • Filed: 05/20/2005
  • Published: 11/23/2006
  • Est. Priority Date: 05/20/2005
  • Status: Abandoned Application
First Claim
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1. A compressed pharmaceutical composition, comprising:

  • a plurality of coated pellets, wherein the coated pellets comprise a pharmaceutically active agent or salt, solvate, hydrate, or polymorph thereof; and

    a compressible mixture, wherein the compressible mixture comprises i) a non-water soluble waxy filler and ii) a disintegrant, and wherein the compressible mixture is in powder form, with the proviso that the compressible mixture is not prepared by extrusion, spheronization, high shear mixing, melt blending, melt pelletization, freeze-drying, or a combination thereof, and wherein the compressed composition exhibits an in vitro dissolution profile according to a USP compendia method that is substantially the same as the dissolution of the coated pellets in the absence of the compressible mixture.

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