Dried blood plasma product

• US 20060263759A1
• Filed: 03/08/2004
• Published: 11/23/2006
• Est. Priority Date: 03/06/2003
• Status: Abandoned Application

• Current Assignee: Sinvent AS
• Original Assignee: Sinvent AS
• Inventors: Eikevik, Tryve Magne, Vjork, Peter, Strommen, Ingvald, Alves-Filho, Odilio, Bergslien, Ola
• Application Number:
  US10/548,294
• Publication Number:
  US 20060263759A1
• Time in Patent Office: Days
• US Class Current: 435/2
• CPC Class Codes: A61K 35/16 Blood plasma; Blood serum umbilical cord blood A61K35/51
• CPC Class Codes: A61P 7/08 Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock artificial tears A61P27/04

Abstract

The present invention provides a fluidized bed dried blood plasma.

Claims

1. A fluidized bed dried blood plasma.

7. The process as claimed in any one of claims 1 to 6, wherein drying is effected to a moisture content of 5 to 12% wt.

8. A method of production of a transfusion liquid, said method comprising dispersing a dried particulate plasma according to claim 1 or produced in any one of claims 2 to 6 in a physiologically tolerable sterile aqueous solution.

9. A kit comprising a first container containing a dried particulate plasma according to claim 1 or produced as claimed in any one of claims 2 to 6, and a second container containing a sterile physiologically tolerable aqueous reconstitution solution.

2. A process for the preparation of a fluidized bed dried blood plasma, said process comprising the steps of:

(A) obtaining a plasma sample from a mammalian subject;

(B) freezing said sample;

(C) granulating the resulting frozen sample;

(D) sieving the resulting granulated frozen sample to remove particles <

400 μ

m;

(E) drying the resulting sieved frozen sample in a fluidized bed dryer at a temperature between −

5°

C. and −

20°

C.; and

(F) optionally, further drying the resulting sieved sample in a fluidized bed dryer at a temperature of −

5°

C. to 45°

C.

3. The process as claimed in claim 2, wherein said granulated frozen sample is sieved to remove particles <

800 μ

m.

4. The process as claimed in claim 2, wherein said sieved sample is further dried in a fluidized bed dryer at a temperature of −

5°

C. to 45°

C.

5. The process as claimed in claim 2, wherein said sieved sample is further dried in a fluidized bed dryer at a temperature of 0°

C. to 30°

C.

6. The process as claimed in claim 2, wherein said sieved sample is further dried in a fluidized bed dryer at a temperature of 10°

C. to 25°

C.