Analyte sensing biointerface

• US 20060263763A1
• Filed: 04/14/2006
• Published: 11/23/2006
• Est. Priority Date: 04/15/2005
• Status: Abandoned Application

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Brauker, James H., Simpson, Peter C.
• Application Number:
  US11/404,946
• Publication Number:
  US 20060263763A1
• Time in Patent Office: Days
• US Class Current: 435/4
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: C12Q 1/001 Enzyme electrodes
• CPC Class Codes: C12Q 1/006 for glucose

Abstract

Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a host using an analyte sensing biointerface.

Claims

1. A sensor for measuring an analyte in a host, the sensor comprising an analyte sensing mechanism disposed within a porous biocompatible matrix.

2. The sensor of claim 1, wherein dimensions of the porous biocompatible matrix comprising the sensing mechanism are less than about 1000 microns.

3. The sensor of claim 1, wherein pores within the porous biocompatible matrix have a size of between about 20 microns and about 1000 microns in at least one dimension.

4. The sensor of claim 1, wherein the porous biocompatible matrix and the sensing mechanism are configured to resist barrier cell layer formation.

5. The sensor of claim 1, wherein the sensing mechanism comprises a working electrode.

6. The sensor of claim 5, wherein the working electrode is a wire electrode.

7. The sensor of claim 5, wherein the working electrode is a substantially planar electrode.

8. The sensor of claim 1, wherein the sensing mechanism further comprises an enzyme domain disposed over the working electrode.

9. The sensor of claim 8, wherein the sensing mechanism further comprises an electrode domain disposed between the enzyme domain in the working electrode.

10. The sensor of claim 8, wherein the sensing mechanism further comprises a resistance domain disposed over the enzyme domain.

11. The sensor of claim 8, wherein the sensing mechanism further comprises a bioprotective domain disposed over the enzyme domain.

12. The sensor of claim 1, wherein the sensing mechanism further comprises a resistance domain disposed between the enzyme domain and the bioprotective domain.

13. The sensor of claim 1, wherein the porous biocompatible matrix comprises a plurality of fibers.

14. The sensor of claim 13, wherein the fibers have a size of between about 1 micron and about 100 microns in at least one dimension.

15. The sensor of claim 13, wherein the plurality of fibers are selected from the group consisting of woven fibers and non-woven fibers.

16. The sensor of claim 1, wherein the porous biocompatible matrix comprises a bioactive agent.

17. An implantable analyte sensor, comprising:

a porous biocompatible matrix; and

a sensing mechanism incorporated into the biocompatible matrix in such a way so that the sensing mechanism and biocompatible matrix manage a foreign body response to resist barrier cell formation and allow transport of analytes to the sensing mechanism when the sensor is implanted into a body.