Controlled flow microfluidic device and method of fabrication

• US 20060263873A1
• Filed: 05/17/2006
• Published: 11/23/2006
• Est. Priority Date: 05/21/2005
• Status: Abandoned Application

• Current Assignee: Antonio J. Ricco, Leanna M. Levine
• Original Assignee: Antonio J. Ricco, Leanna M. Levine
• Inventors: Ricco, Antonio J., Levine, Leanna M.
• Application Number:
  US11/436,119
• Publication Number:
  US 20060263873A1
• Time in Patent Office: Days
• US Class Current: 435/287.200
• CPC Class Codes: B01D 2325/028 Microfluidic pore structures
• CPC Class Codes: B01D 61/18 Apparatus therefor
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2300/0887 Laminated structure
• CPC Class Codes: B01L 2400/0487 fluid pressure, pneumatics
• CPC Class Codes: B01L 2400/084 Passive control of flow resistance
• CPC Class Codes: B01L 3/502707 characterised by the manufacture of the container or its components by shaping or joining plastic parts B29C59/00, B29C65/00; by laminating B32B37/00; manufacture of microstructural devices in general B81C
• CPC Class Codes: B01L 3/502746 characterised by the means for controlling flow resistance, e.g. flow controllers, baffles B01L3/502738 takes precedence
• CPC Class Codes: C12M 23/12 Well or multiwell plates C12M25/04 takes precedence
• CPC Class Codes: C12M 23/16 Microfluidic devices; Capillary tubes integrated microfluidic structures B01L3/5027; microreactors B01J19/0093
• CPC Class Codes: C12M 29/04 Filters; Permeable or porous membranes or plates, e.g. dialysis
• CPC Class Codes: C12M 41/00 Means for regulation, monitoring, measurement or control, e.g. flow regulation controlling or regulating chemical, physical or physicochemical processes B01J19/0006; heating or cooling apparatus for laboratory use B01L7/00; electro optical investigation of individual particles, flow cytometers G01N15/14; automatic analysis G01N35/00; controlling or regulating in general G06N

Abstract

The invention comprises a method and device for cell culture analysis using microporous membranes to control fluid flow in a device. The microporous membranes are of defined porosity and surface area to effectively increase the fluidic circuit resistance and control fluid flow through the device.

Claims

1. A device for cell culture analysis using microporous membranes of defined porosity and surface area to control fluid flow through increased resistance in the fluidic circuit of the device.