Methods for treating pain using smooth muscle modulators and a2 subunit calcium channel modulators
First Claim
1. A method for treating pain, which comprises administering to an individual in need thereof a therapeutically effective amount of a first component that is an α
-
2δ
subunit calcium channel modulator, in combination with a second component that is a smooth muscle modulator.
1 Assignment
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Accused Products
Abstract
A method is provided for using α2δ subunit calcium channel modulators or other compounds that interact with the α2δ calcium channel subunit in combination with one or more compounds with smooth muscle modulatory effects to treat pain. According to the present invention, α2δ subunit calcium channel modulators include GABA analogs (e.g., gabapentin and pregabalin), fused bicyclic or tricyclic amino acid analogs of gabapentin, and amino acid compounds. Compounds with smooth muscle modulatory effects include antimuscarinics, β3 adrenergic agonists, spasmolytics, neurokinin receptor antagonists, bradykinin receptor antagonists, and nitric oxide donors.
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Citations
38 Claims
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1. A method for treating pain, which comprises administering to an individual in need thereof a therapeutically effective amount of a first component that is an α
-
2δ
subunit calcium channel modulator, in combination with a second component that is a smooth muscle modulator. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
-
2δ
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22. A method for treating pain comprising administering to an individual in need thereof a therapeutically effective amount of at least one component selected from an α
-
2δ
subunit calcium channel modulator and a smooth muscle modulator.
-
2δ
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23. A pharmaceutical composition comprising a first component that is an α
-
2δ
subunit calcium channel modulator, in combination with a second component that is a smooth muscle modulator, wherein said first component and said second component are in amounts sufficient to treat pain.
-
2δ
- 24. A pharmaceutical composition comprising a first component that is Gabapentin or pharmaceutically acceptable acids, salts, esters, amides, prodrugs, or active metabolites thereof, in combination with a second component that is Oxybutynin or pharmaceutically acceptable acids, salts, esters, amides, prodrugs, or active metabolites thereof, wherein said first component and said second component are in amounts sufficient to treat pain.
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29. A pharmaceutical composition comprising a first component that is Pregabalin or pharmaceutically acceptable acids, salts, esters, amides, prodrugs, or active metabolites thereof, in combination with a second component that is Oxybutynin or pharmaceutically acceptable acids, salts, esters, amides, prodrugs, or active metabolites thereof, wherein said first component and said second component are in amounts sufficient to treat pain.
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30. A pharmaceutical composition for the treatment of pain, comprising a first component that is Gabapentin or pharmaceutically acceptable acids, salts, esters, amides, prodrugs, or active metabolites thereof, in combination with a second component that is Oxybutynin or pharmaceutically acceptable acids, salts, esters, amides, prodrugs, or active metabolites thereof, wherein said first component and said second component are present in a ratio from about 1:
- 1 to about 800;
1 or from about 1;
1 to about 1;
800, respectively, based on a fraction of their respective ED50 values.
- 1 to about 800;
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31. A combination for the treatment of pain, comprising a first component that is Gabapentin or pharmaceutically acceptable acids, salts, esters, amides, prodrugs, or active metabolites thereof, in combination with a second component that is Oxybutynin or pharmaceutically acceptable acids, salts, esters, amides, prodrugs, or active metabolites thereof, wherein said first component and said second component are in a weight/weight ratio of from 1:
- 1 to about 800;
1 or from about 1;
1 to about 1;
800, respectively.
- 1 to about 800;
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32. A pharmaceutical composition for the treatment of pain comprising Oxybutynin, wherein said Oxybutynin is in an amount less than about 5.0 mg.
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33. A packaged kit for a patient to use in the treatment of pain, comprising:
- at least one component selected from an α
2δ
subunit calcium channel modulator and a smooth muscle modulator;
a container housing said component or components during storage and prior to administration; and
instructions for carrying out drug administration of an α
2δ
subunit calcium channel modulator with a smooth muscle modulator in a manner effective to treat pain. - View Dependent Claims (34, 35, 36, 37, 38)
- at least one component selected from an α
Specification