Method for the treatment of sexual dysfunction due to medical conditions

• US 20060264512A1
• Filed: 05/17/2006
• Published: 11/23/2006
• Est. Priority Date: 05/19/2005
• Status: Abandoned Application

• Current Assignee: Boehringer Ingelheim International GmbH (C.H. Boehringer Sohn AG & Co. KG)
• Original Assignee: Boehringer Ingelheim International GmbH (C.H. Boehringer Sohn AG & Co. KG)
• Inventors: Pyke, Robert
• Application Number:
  US11/383,796
• Publication Number:
  US 20060264512A1
• Time in Patent Office: Days
• US Class Current: 514/571
• CPC Class Codes: A61K 31/192 having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid cannabinoids A61K31/658
• CPC Class Codes: A61K 31/496 Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 1/16 for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 13/02 of urine or of the urinary tract, e.g. urine acidifiers
• CPC Class Codes: A61P 13/08 of the prostate
• CPC Class Codes: A61P 13/10 of the bladder
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 15/08 for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
• CPC Class Codes: A61P 15/10 for impotence
• CPC Class Codes: A61P 15/12 for climacteric disorders
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 25/08 Antiepileptics; Anticonvulsants
• CPC Class Codes: A61P 25/16 Anti-Parkinson drugs
• CPC Class Codes: A61P 25/18 Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
• CPC Class Codes: A61P 25/20 Hypnotics; Sedatives
• CPC Class Codes: A61P 25/22 Anxiolytics
• CPC Class Codes: A61P 25/24 : Antidepressants
• CPC Class Codes: A61P 29/02 : without antiinflammatory effect
• CPC Class Codes: A61P 3/06 : Antihyperlipidemics
• CPC Class Codes: A61P 3/10 : for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 31/18 : for HIV
• CPC Class Codes: A61P 35/00 : Antineoplastic agents
• CPC Class Codes: A61P 35/02 : specific for leukemia
• CPC Class Codes: A61P 7/00 : Drugs for disorders of the blood or the extracellular fluid
• CPC Class Codes: A61P 7/06 : Antianaemics

Abstract

The invention relates to a method for the treatment of sexual dysfunctions caused by medical conditions comprising the administration of a therapeutically effective amount of flibanserin.

Claims

1. ) A method for the treatment of a sexual dysfunction caused by a medical condition comprising the administration of a therapeutically effective amount of flibanserin, or a pharmacologically acceptable acid addition salt thereof, or a hydrate or a solvate thereof.

2. ) The method for the treatment of a sexual dysfunction caused by a medical condition according to claim 1, wherein the sexual dysfunction is selected from the group consisting of sexual desire disorders caused by a medical condition, sexual arousal disorders caused by a medical condition, orgasmic disorders caused by a medical condition, sexual pain disorders caused by a medical condition and combinations thereof.

3. ) The method according to claim 1, wherein the sexual dysfunction is a sexual desire disorder caused by a medical condition.

4. ) The method according to claim 1, wherein the sexual dysfunction is a sexual arousal disorder caused by a medical condition.

5. ) The method according to claim 1, wherein the sexual dysfunction is an orgasmic disorder caused by a medical condition.

6. ) The method according to claim 1, wherein the sexual dysfunction is a sexual pain disorder caused by a medical condition.

7. ) The method according to claim 1, wherein the sexual dysfunction has been caused by a medical condition selected from the group consisting of androgen insufficiency, adrenealectomy, arthritis, chronic fatigue, coronary heart disease, depression, diabetes (type 1 and 11), epilepsy, HIV-infection, hyperprolactinemia, hypogonadism, hypopituitarism, hysterectomy, rectal resection, lower urinary tract symptoms (LUTS) caused by benign prostatic hypertrophy, overactive bladder, stress urinary incontinence, vulvar vestibulitis, interstitial cystitis, multiple sclerosis, oophorectomy, Parkinson'"'"'s disease, perimenopausal states, postmenopausal states, postpartum states, prostatectomy, radiotherapeutic treatment of cervical cancer, schizophrenia, spinal cord injury, stroke, uraemia, anxiety disorders, somatisation disorder, insomnia, chronic pain syndromes, restless legs syndrome, sleep apnea, chronic forms of hepatitis, irritable bowel syndrome, any form of cance, myelofibrosis, any form of anemia and seasonal allergies with systemic disability.

8. ) The method according claim 1, wherein flibanserin is in the form of a pharmaceutically acceptable acid addition salt, wherein the pharmaceutically acceptable acid addition salt is formed by an acid selected from the group consisting of succinic acid, hydrobromic acid, acetic acid, fumaric acid, maleic acid, methanesulphonic acid, lactic acid, phosphoric acid, hydrochloric acid, sulphuric acid, tartaric acid, citric acid, and mixtures thereof.

9. ) The method according to claim 1, wherein flibanserin is in the form of flibanserin polymorph A.