Photoacoustic assay method and apparatus
First Claim
1. A method of assaying an analyte in a body part comprising:
- illuminating the body part with at least one pulse of light at each of first and second wavelengths that stimulates photoacoustic waves in a first, target, region and a second, reference, region of the body part, wherein the reference region interfaces with the target region and has at least one known optoacoustic property and wherein light at the first wavelength is absorbed and/or scattered by the analyte;
sensing pressure in the photoacoustic waves from the target and reference regions stimulated by the light at the first and second wavelengths; and
using the sensed pressures and the at least one known optoacoustic property to assay the analyte in the target region
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Abstract
A method of assaying an analyte in a body part comprising: illuminating the body part with at least one pulse of light at each of first and second wavelengths that stimulates photoacoustic waves in a first, target, region and a second, reference, region of the body part, wherein the reference region interfaces with the target region and has at least one known optoacoustic property and wherein light at the first wavelength is absorbed by the analyte; sensing pressure in the photoacoustic waves from the target and reference regions stimulated by the light at the first and second wavelengths; and using the sensed pressures and the at least one known optoacoustic property to assay the analyte in the target region.
131 Citations
62 Claims
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1. A method of assaying an analyte in a body part comprising:
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illuminating the body part with at least one pulse of light at each of first and second wavelengths that stimulates photoacoustic waves in a first, target, region and a second, reference, region of the body part, wherein the reference region interfaces with the target region and has at least one known optoacoustic property and wherein light at the first wavelength is absorbed and/or scattered by the analyte;
sensing pressure in the photoacoustic waves from the target and reference regions stimulated by the light at the first and second wavelengths; and
using the sensed pressures and the at least one known optoacoustic property to assay the analyte in the target region - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 62)
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- 16. A method according to 15 and comprising choosing the first and second wavelengths so that reflectance at the interface between the target region and the first layer is substantially the same for light at the first and second wavelengths.
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59. A method of assaying an analyte in a body part comprising:
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illuminating the body part with at least one pulse of light that is absorbed and/or scattered by the analyte and stimulates photoacoustic waves in a first, target, region and a second, reference, region of the body part, wherein the reference region interfaces with the target region and has at least one known optoacoustic property;
sensing pressure in the photoacoustic waves from the target and reference regions stimulated by the light; and
using the sensed pressures and the at least one known optoacoustic property to assay the analyte in the target region - View Dependent Claims (60, 61)
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Specification