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Method for data reduction and calibration of an OCT-based blood glucose monitor

  • US 20060264719A1
  • Filed: 04/13/2006
  • Published: 11/23/2006
  • Est. Priority Date: 08/11/2004
  • Status: Active Grant
First Claim
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1. A noninvasive method of determining estimated blood glucose levels in a biological tissue of a subject using an optical coherence tomography-based blood glucose monitor comprising a sensor and at least one algorithm, the method comprising the steps:

  • (a) selecting a wavelength of light for which μ

    s, an absorption coefficient of the biological tissue, is small relative to μ

    s, a scattering efficient of the tissue for the selected wavelength of light;

    (b) continuously scanning a two-dimensional surface area of the biological tissue and interferometrically scanning the two-dimensional surface area of the biological tissue in a depth dimension with the light during a time period;

    (c) averaging the data obtained by interferometrically scanning the two-dimensional surface area of the biological tissue in a depth dimension with the light to generate a multitude of optical coherence tomography scan data lines in the time period, wherein the x-axis of each optical coherence tomography scan data line is depth and the y-axis of each optical coherence tomography scan data lines is intensity;

    (d) calibrating the optical coherence tomography-based sensor against at least two invasively obtained blood glucose measurements taken during the time period; and

    (e) allowing the calibrated optical coherence tomography-based sensor and the at least one algorithm to determine an estimated blood glucose level in the biological tissue.

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