Systems and methods for conducting animal studies
First Claim
Patent Images
1. A method of obtaining pharmacological data useful for assessing efficacy and/or toxicity of a therapeutical agent from a test animal, comprising a) providing a fluidic device comprising at least one sample collection unit, an assay assembly;
- and a plurality of channels in fluid communication with said sample collection unit and/or said assay assembly;
b) allowing a sample of biological fluid of less than about 50 ul to react with reactants contained within said assay assembly to yield a detectable signal generated from an analyte initially collected in said sample that is indicative of a pharmacological parameter; and
c) detecting said detectable signal; and
d) repeating the reaction and detection steps with a second sample of biological fluid from the same test animal.
7 Assignments
0 Petitions
Accused Products
Abstract
This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.
197 Citations
19 Claims
-
1. A method of obtaining pharmacological data useful for assessing efficacy and/or toxicity of a therapeutical agent from a test animal, comprising
a) providing a fluidic device comprising at least one sample collection unit, an assay assembly; - and a plurality of channels in fluid communication with said sample collection unit and/or said assay assembly;
b) allowing a sample of biological fluid of less than about 50 ul to react with reactants contained within said assay assembly to yield a detectable signal generated from an analyte initially collected in said sample that is indicative of a pharmacological parameter; and
c) detecting said detectable signal; and
d) repeating the reaction and detection steps with a second sample of biological fluid from the same test animal. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
- and a plurality of channels in fluid communication with said sample collection unit and/or said assay assembly;
-
2. A method of obtaining pharmacological data useful for assessing efficacy and/or toxicity of a therapeutical agent from a test animal, comprising.
a) providing a fluidic device comprising at least one sample collection unit, an assay assembly; - and a plurality of channels in fluid communication with said sample collection unit and/or said assay assembly;
b) allowing a sample of biological fluid to react with reactants contained within said assay assembly to yield a detectable signal generated from an analyte initially collected in said sample that is indicative of a pharmacological parameter; and
c) detecting said detectable signal; and
d) repeating the reaction and detection steps with a second sample of biological fluid from the same test animal, wherein the animal is not subjected to anesthesia.
- and a plurality of channels in fluid communication with said sample collection unit and/or said assay assembly;
Specification