Device and kit for delivery of encapsulated substances and methods of use thereof

• US 20060264804A1
• Filed: 04/05/2006
• Published: 11/23/2006
• Est. Priority Date: 04/07/2005
• Status: Abandoned Application

• Current Assignee: Power Paper Ltd. (Products To Go, Inc.)
• Original Assignee: Power Paper Ltd. (Products To Go, Inc.)
• Inventors: Karmon, Yoram, Shahar, Michal, Mavor, Daniela, Harel, Nurit
• Application Number:
  US11/397,864
• Publication Number:
  US 20060264804A1
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A61N 1/0412 Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
• CPC Class Codes: A61N 1/042 Material of the electrode
• CPC Class Codes: A61N 1/0428 Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
• CPC Class Codes: A61N 1/0436 Material of the electrode
• CPC Class Codes: A61N 1/0448 Drug reservoir

Abstract

The present invention is of a kit and electricity generating device for delivery of an encapsulated composition or mixture of compositions, including an electricity generating device and at least one composition in an encapsulated carrier vehicle which is contacted or applied to the electricity generating device. In some embodiments the device includes a means for maintaining stability of the encapsulated composition prior to bio-membrane penetration. The present invention also provides methods of use thereof. Furthermore, the present invention provides a device and method for delivering a fixed ratio of compounds from a mixture to a bio-membrane comprising the step of electro-transporting an encapsulated mixture of compounds. Still further, the present invention is of a device and method for delivering each compound of a mixture of compounds to the same penetration depth.

Claims

1. An integrated electricity generating device for delivery of an encapsulated composition to a bio-membrane, comprising:

(a) an electricity generating device;

(b) at least one composition in an encapsulated carrier vehicle in contact with the electricity generating device; and

(c) means for maintaining stability of an encapsulated composition before bio-membrane penetration.

2. The integrated electricity generating device of claim 1, wherein the electricity generating device is selected from the group consisting of an electro-transportation device, iontophoresis device, a bio-membrane patch, a dermal patch, a galvanic stimulation device, an electrokinetic device, an electroporation device, a microneedle, a TENS device, an ultrasound device and a combination thereof.

3. The integrated electricity generating device of claim 2, wherein the dermal patch comprises

at least one active electrode,

at least one counter electrode;

and

a power source for supplying power to the device.

4. The integrated electricity generating device of claim 3, wherein the power source is a flexible thin layer electrochemical cell.

5. The integrated electricity generating device of claim 4, wherein the flexible thin layer electrochemical cell is an open liquid state electrochemical cell which comprises a first layer of insoluble negative pole, a second layer of insoluble positive pole and a third layer of aqueous electrolyte, the third layer being disposed between the first and second layers and including:

(a) a deliquescent material for keeping the open cell wet at all times;

(b) an electroactive soluble material for obtaining required ionic conductivity; and

(c) a water-soluble polymer for obtaining a required viscosity for adhering the first and the second layers to the third layer.

6. The integrated electricity generating device of claim 1, wherein the electricity generating device facilitates one of the group consisting of electrical stimulation, electrical driven delivery of a substance, introduction of current and voltage to a bio-membrane and a combination thereof.

7. The integrated electricity generating device of claim 1, wherein the at least one composition is selected from the group consisting of a pharmaceutical, a cosmetic, a cosmeceutical, a formulation additive, an active formulation, an inactive composition, a charged composition, an uncharged composition, a decorative formulation and a combination thereof.

8. The integrated electricity generating device of claim 7, wherein the at least one composition is a plurality of compositions.

9. The integrated electricity generating device of claim 8, wherein the plurality of compositions is a mixture of same charged compositions, oppositely charged compositions, uncharged compositions, a mixture of charged and uncharged compositions, hydrophilic compositions, hydrophobic compositions, mixtures of hydrophilic and hydrophobic compositions and a combination thereof.

10. The integrated electricity generating device of claim 1, wherein the encapsulating vehicle carrier is selected from the group consisting of a micro-encapsulated vehicle, a sub micro encapsulated vehicle, a nano-encapsulated vehicle and a combination thereof.

11. The integrated electricity generating device of claim 1, wherein the encapsulating carrier vehicle is selected from the group consisting of vesicles, rigid vesicles, elastic vesicles, monolayer vesicles, multi-layer vesicles, liposomes, niosomes, proniosomes, transfersomes®

, ethosomes, L-595-PEG-8-L vesicles, nanoemulsions, nanosomes, nanoparticles and a combination thereof.

12. The integrated electricity generating device of claim 1, wherein the encapsulating carrier vehicle is selected from the group consisting of a positively charged vehicle, a negatively charged vehicle, an uncharged vehicle and a combination thereof.

13. The integrated electricity generating device of claim 1, wherein the encapsulated composition is contacted with the electricity generating device by being disposed under an electrode selected from the group consisting of positive electrode, negative electrode and combination thereof.

14. The integrated electricity generating device of claim 13, wherein the encapsulated composition is at least one of integrally formed with at least one of the electrodes of the electricity generated device, applied onto at least one of the electrodes, or disposed in a conductive fluid.

15. The integrated electricity generating device of claim 13, wherein the encapsulated composition is separated from direct contact with the electrode by a conductive separator.

16. The integrated electricity generating device of claim 1, wherein the means for maintaining stability of encapsulated composition prior to bio-membrane penetration is selected from the group consisting of a direct contact separator, current control, low current, low charge on encapsulating carrier vehicle, heat control, cooling means and a combination thereof.

17. The integrated electricity generating device of claim 1, wherein the bio-membrane is selected from the group consisting of skin, mucosa, eye membrane, nail, hair, oral membrane, vaginal membrane, rectal membrane and a combination thereof.

18. The integrated electricity generating device of claim 1, for use in the treatment and prevention of a condition selected from the group consisting of a skin condition, acne treatment, sebum regulation, rosacea, age spots, dermatitis, skin and nail viral, fungal and bacterial infections, onychomycosis, disorders of the hair follicles and sebaceous glands, scaling disease, dark rings under the eyes, scars, wounds, cellulite treatment, skin and tooth whitening, pigmentation disorders, sun damaged skin, fine facial lines, laugh lines, aging skin, dry skin, wrinkles, puffy eyes, lifting skin, folliculitis, dermatitis, psoriasis, warts, benign tumors, malignant tumors, pain management, bone healing, facilitating muscle contraction, promoting metabolic processes, increasing blood flow, hair growth disorders, treating hyperhidrosis, body decoration, vaginal candidiasis and vaginosis, genital herpes, anaesthesia and a combination thereof.

19. The integrated electricity generating device of claim 1 as part of a kit.

20. A method of delivering a fixed ratio of compounds from a mixture of compounds to and/or into and/or through a bio-membrane comprising the step of electro-transporting an encapsulated mixture of compounds, wherein the mixture of compounds includes a predetermined fixed ratio of compounds.

21. The method of claim 20, wherein the mixture of compounds is selected from the group consisting of same compounds, different compounds, different size compounds, same size compounds, different charged compounds, same charged compounds, same amount of charged compounds, different amount of charged compounds, different physical states of compounds, same states of compounds, compounds with different hydrophobicity, immiscible compounds, miscible compounds, compounds with different or the same therapeutic and/or cosmetic properties and a combination thereof.

22. The method of claim 20, wherein the electro-transporting includes delivery of a ratio of compounds that is the same as the fixed ratio of compounds encapsulated.

23. The method of claim 20, wherein the electro-transporting is facilitated by an electricity generating device selected from the group consisting of an electro-transportation device, iontophoresis device, a bio-membrane patch, a dermal patch, a galvanic stimulation device, an electrokinetic device, an electroporation device, a TENS device, an ultrasound device and a combination thereof.

24. The method of claim 20, wherein the electro-transporting includes delivery of each of the compounds in the encapsulated mixture to the same penetration depth.

25. The method of claim 24, wherein the penetration depth is controlled by factors selected from the group consisting of type of encapsulation vesicles, rigid or elastic vesicles, size of vesicles, charge on vesicles, device current and voltage and a combination thereof.

26. An integrated electricity generating device for delivery of a fixed ratio of compounds in a mixture to a target site, comprising:

(a) an electricity generating device; and

(b) a mixture of compounds in a fixed ratio in an encapsulated carrier vehicle in contact with the electricity generating device;

wherein the electricity generating device promotes delivery of the encapsulated mixture to the target site and facilitates delivery at the target site of the fixed ratio of compounds in the mixture.

27. An electricity generating device for delivery of a mixture of compounds to the same penetration depth, comprising:

(a) an electricity generating device; and

(b) a mixture of compounds in an encapsulated carrier vehicle in contact with the electricity generating device;

wherein the electricity generating device promotes delivery of the encapsulated mixture of compounds to a target site and facilitates delivery of the mixture of compounds to the same penetration depth.

28. The electricity generating device of claim 27, wherein the encapsulated carrier is configured to release the mixture of compounds at the target site.