Probe device for electrical stimulation and recording of the activity of excitable cells
First Claim
1. A probe device for electrical stimulation and recording of activity of excitable cells in a tissue, the probe device comprising an array of pixels located on a die positioned on a substrate, wherein each pixel comprises at least one stimulation means and at least one recording means, and wherein the substrate is shaped so as to enable, when introduced into tissue of a patient, 3D stimulation of excitable cells present in the tissue and 3D measurement of excitable cell activity.
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Accused Products
Abstract
A probe device is described having a substrate and a die on top of the substrate. The die has an array of stimulation/recording sites having at least one stimulation means and at least one recording means. The substrate comprising the die is folded into a cylindrical shape or a shape with a conical cross-section and, therefore, causes substantially no damage when it is implanted in tissue to be examined or treated, e.g., the brain of a patient in case of a neuro-probe device for use in deep brain stimulation.
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Citations
20 Claims
- 1. A probe device for electrical stimulation and recording of activity of excitable cells in a tissue, the probe device comprising an array of pixels located on a die positioned on a substrate, wherein each pixel comprises at least one stimulation means and at least one recording means, and wherein the substrate is shaped so as to enable, when introduced into tissue of a patient, 3D stimulation of excitable cells present in the tissue and 3D measurement of excitable cell activity.
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9. A method for the manufacturing of a probe device for electrical stimulation and recording of activity of excitable cells in a tissue, the method comprising:
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providing an array of pixels on a die, each pixel comprising at least one stimulation means and at least one recording means; and
thinning the die comprising the array of pixels. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
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17. A method for determining a stimulation pattern for application to excitable cells in a tissue, using a probe-device comprising an array of pixels located on a die positioned on a substrate, wherein each pixel comprises at least one stimulation means and at least one recording means, and wherein the substrate is shaped so as to enable, when introduced into tissue of a patient, 3D stimulation of excitable cells present in the tissue and 3D measurement of excitable cell activity, the method comprising:
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recording electrical activity of excited cells;
comparing said recorded electrical activity to predetermined activity values of said excited cells; and
determining the stimulation pattern from said comparison. - View Dependent Claims (18)
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19. A device for determining a stimulation pattern for application to excitable cells in a tissue by means of a probe device comprising an array of pixels located on a die positioned on a substrate, wherein each pixel comprises at least one stimulation means and at least one recording means, and wherein the substrate is shaped so as to enable, when introduced into tissue of a patient, 3D stimulation of excitable cells present in the tissue and 3D measurement of excitable cell activity, the device comprising:
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a probe device for recording electrical activity of excited cells and generating corresponding activity signals, wherein the probe device has an array of pixels, wherein each pixel comprises at least one stimulation means and at least one recording means;
processing means for comparing the generated activity signals with predetermined activity signals for the excited cells; and
stimulation pattern determining means for generating, from said comparison, stimulation pattern parameters of the stimulation pattern. - View Dependent Claims (20)
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Specification