Antisense restenosis composition and method
First Claim
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1. A method for treating a vascular injury site in a human patient by reducing restenosis at the site, said method comprising administering to the patient, by intravascular delivery, an antisense compound having:
- (i) morpholino subunits linked together by phosphorodiamidate linkages, 2 atoms long, joining the morpholino nitrogen of one subunit to the 5′
exocyclic carbon of an adjacent subunit, and (ii) a sequence of bases attached to the subunits and containing the sequence identified by SEQ ID NO;
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Abstract
The present invention provides an improved method for reducing the risk or severity of restenosis following cardiac angioplasty. The method includes administering to a target vessel region, a morpholino antisense compound having uncharged phosphorus-containing backbone linkages, and spanning the start codon of a human c-myc mRNA. Also disclosed are novel antisense compounds and compositions, and a method for assaying the effectiveness of antisense delivery and uptake to a target vessel region.
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17 Claims
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1. A method for treating a vascular injury site in a human patient by reducing restenosis at the site, said method comprising administering to the patient, by intravascular delivery, an antisense compound having:
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(i) morpholino subunits linked together by phosphorodiamidate linkages, 2 atoms long, joining the morpholino nitrogen of one subunit to the 5′
exocyclic carbon of an adjacent subunit, and(ii) a sequence of bases attached to the subunits and containing the sequence identified by SEQ ID NO;
1. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A morpholino antisense compound having:
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(i) morpholino subunits linked together by phosphorodiamidate linkages, 2 atoms long, joining the morpholino nitrogen of one subunit to the 5′
exocyclic carbon of an adjacent subunit, and(ii) a sequence of bases attached to the subunits and containing the sequence identified by SEQ ID NO;
1, for the preparation of a pharmaceutical composition for use in inhibiting restenosis in a patient. - View Dependent Claims (15, 16, 17)
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14. A morpholino antisense compound having (i) from 8 to 40 nucleotides, including a targeting nucleic acid sequence complementary to a region that spans the start codon of a human c-myc mRNA gene, and (ii) phosphorous-containing intersubunit linkages.
Specification