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Probes

  • US 20060269916A1
  • Filed: 11/19/2003
  • Published: 11/30/2006
  • Est. Priority Date: 11/22/2002
  • Status: Abandoned Application
First Claim
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1. A nucleic acid probe for detecting a target nucleic acid sequence comprising two or more cis-located nucleic acid regions, the probe comprising two or more non-contiguous nucleic acid regions capable of hybridizing with respective cis-located nucleic acid regions on the target sequence, the non-contiguous regions being separated by one or more spacer regions comprising at least predominantly material which will not hybridize with the target sequence in the region between the cis-located regions and having a length selected with regard to the target sequence effectively to maintain correct spatial orientation of the non-contiguous hybridizing regions on the probe with the cis-located regions on the target sequence such that base-base pairwise hybridization there between can be effected in use of the probe, the probe comprising one or more nucleic acids matched for hybridization with corresponding one or more nucleic acids in the target sequence in the region between the cis-located regions and/or the two or more non-contiguous nucleic acids being separated by the spacer region comprising a sequence of molecules, each of which are the same, or a similar size to a nucleic acid base.

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