Water relaxation-based sensors
First Claim
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1. A water relaxation-based sensor for detecting the presence of an analyte in a sample, the sensor comprising:
- (i) a walled enclosure enveloping a chamber, wherein the wall comprises an opening for passage of the analyte into and out of the chamber;
(ii) a plurality of magnetic nanoparticles located within the chamber, each nanoparticle having at least one moiety that is covalently or noncovalently linked to the nanoparticle; and
optionally, (iii) at least one binding agent located within the chamber;
wherein the opening is smaller in size than the nanoparticles, and is larger in size than the analyte; and
wherein the moiety and the analyte each bind reversibly to the binding agent, when present;
or the analyte binds reversibly to the moiety.
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Abstract
This invention relates to magnetic resonance-based sensors and related methods.
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Citations
51 Claims
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1. A water relaxation-based sensor for detecting the presence of an analyte in a sample, the sensor comprising:
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(i) a walled enclosure enveloping a chamber, wherein the wall comprises an opening for passage of the analyte into and out of the chamber;
(ii) a plurality of magnetic nanoparticles located within the chamber, each nanoparticle having at least one moiety that is covalently or noncovalently linked to the nanoparticle; and
optionally,(iii) at least one binding agent located within the chamber;
wherein the opening is smaller in size than the nanoparticles, and is larger in size than the analyte; and
wherein the moiety and the analyte each bind reversibly to the binding agent, when present;
or the analyte binds reversibly to the moiety. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51)
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Specification