Portable drug delivery device including a detachable and replaceble administration or dosing element
First Claim
1. An apparatus for delivering a liquid, comprising:
- an active assembly comprising a controller and a power source;
a passive assembly adapted for mechanically coupling and decoupling with the active assembly, the passive assembly comprising a dispensing reservoir containing the liquid; and
a dispensing mechanism comprising an active portion in the active assembly providing a motive force to draw the liquid from the dispensing reservoir and a passive portion in the passive assembly proximate the active portion and defining a feed chamber through which the liquid flows from the dispensing reservoir.
3 Assignments
0 Petitions
Accused Products
Abstract
A device for transdermal drug delivery and administration of differing dosages at specific times of the day automatically pursuant to a pre-programmed dosage profile. The device includes a control and display unit, a two-part dispensing mechanism, a drug reservoir, an administration element, and a solvent removal element. The dispensing mechanism may be a peristaltic pump having an active portion with a motor, a roller, a mounting plate and a detachable passive portion with tubing and a housing. The motor and roller are mounted in the reusable portion of the delivery device with the control unit and a power source. The speed of the micromotor is controlled by the control unit, so that the turning speed of the roller is controlled which, in turn, controls the flow rate to the administration. The passive portion and drug reservoir are detachable along with the administration element for attaching a new dosing reservoir.
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Citations
30 Claims
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1. An apparatus for delivering a liquid, comprising:
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an active assembly comprising a controller and a power source;
a passive assembly adapted for mechanically coupling and decoupling with the active assembly, the passive assembly comprising a dispensing reservoir containing the liquid; and
a dispensing mechanism comprising an active portion in the active assembly providing a motive force to draw the liquid from the dispensing reservoir and a passive portion in the passive assembly proximate the active portion and defining a feed chamber through which the liquid flows from the dispensing reservoir. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A transdermal drug delivery device, comprising:
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a drug reservoir for containing a liquid comprising a solvent and active substance mixture;
a peristaltic pump comprising an active portion including a motor, a roller driven by the motor, and two or more shoes attached to the roller and a passive portion including a tube with a first end connected to the drug reservoir and a pump housing for detachably receiving the active portion such that the shoes compress the tube when the roller is driven by the motor; and
an administration assembly comprising an administration reservoir connected to a second end of the tube for receiving the liquid from peristaltic pump and a membrane permeable to the active substance in fluid communication with the administration reservoir. - View Dependent Claims (12, 13, 14, 15, 16)
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17. A peristaltic micropump, comprising:
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an active portion comprising an electric motor, a shaft driven by the motor, a roller plate connected to the shaft, and a plurality of shoes rotatably mounted to the roller plate; and
a passive portion comprising compressible tubing and a housing for supporting the electric motor, the housing having a recessed surface adapted for receiving the roller plate and a compression surface, wherein a length of the compressible tubing is positioned in contact with the compression surface and in contact with at least one of the shoes. - View Dependent Claims (18, 19, 20)
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21. An apparatus for delivering a drug formulation and stopping dosing or delivery in a controllable manner, comprising:
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an active assembly comprising a controller;
a passive assembly adapted for mechanically coupling and decoupling with the active assembly, the passive assembly comprising a dispensing reservoir containing the drug formulation and a delivery element with an administration reservoir and a membrane in fluid communication with the administration reservoir, the membrane being permeable to an active substance in the drug formulation;
a dispensing mechanism comprising an active portion in the active assembly providing a motive force to draw the drug formulation from the dispensing reservoir to the administration reservoir and a passive portion in the passive assembly proximate the active portion and defining a feed chamber through which the drug formulation flows from the dispensing reservoir; and
means for flushing the administration reservoir to remove the drug formulation, whereby dosing can be stopped. - View Dependent Claims (22, 23, 24, 25)
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26. A transdermal drug delivery device, comprising:
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means for storing a first liquid and a second liquid each comprising a solvent and active substance mixture;
a pump comprising an active portion including a motor and a passive portion including a pair of feed channels connected to the storing means and a pump housing for detachably receiving the active portion; and
an administration assembly comprising a reservoir connected to the feed channels for receiving the first and second liquids when pumped from the storing means by the pump and a membrane permeable to the active substances in fluid communication with the administration reservoir. - View Dependent Claims (27, 28)
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29. A transdermal drug delivery device, comprising:
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means for storing a liquid comprising a solvent and an active substance;
a dispensing mechanism comprising a feed channel connected to the drug reservoir;
an administration assembly comprising an administration reservoir connected to the feed channel for receiving the liquid from the storing means when pumped by the pump and a membrane permeable to the active substances in fluid communication with the administration reservoir, wherein the administration assembly further comprises a heating element operable to apply heat to the administration reservoir and the membrane; and
a controller operating automatically based on a dosing profile to control operations of the dispensing mechanism and the heating element, whereby permeation is enhanced by selective operation of the heating element. - View Dependent Claims (30)
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Specification