Methods and apparatus for treating contrast nephropathy
First Claim
1. A method for treating contrast nephropathy, the method comprising:
- introducing modulation apparatus to a vicinity of a neural fiber that contributes to renal function of a kidney of a patient that is experiencing contrast nephropathy; and
modulating a function of the neural fiber via the modulation apparatus;
wherein modulating the function of the neural fiber further comprises modulating the function without completely physically severing the neural fiber.
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Abstract
Methods and apparatus are provided for treating contrast nephropathy, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
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Citations
20 Claims
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1. A method for treating contrast nephropathy, the method comprising:
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introducing modulation apparatus to a vicinity of a neural fiber that contributes to renal function of a kidney of a patient that is experiencing contrast nephropathy; and
modulating a function of the neural fiber via the modulation apparatus;
wherein modulating the function of the neural fiber further comprises modulating the function without completely physically severing the neural fiber. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for treating contrast nephropathy, the method comprising:
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percutaneously introducing modulation apparatus to a vicinity of a neural fiber that contributes to renal function of a kidney of a patient that is experiencing contrast nephropathy; and
modulating a function of the neural fiber via the modulation apparatus. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification