Method and compositions for treatment of epithelial damage
First Claim
1. A method for treating or preventing epithelial lining tissue damage from mucositis induced by radiation exposure and/or chemotherapy, said method comprising applying to mucosa or other tissues of the body an amount of a therapeutic composition which comprises at least one histone deacetylase (HDAC) inhibitor formulated with or without at least one pharmaceutically acceptable biocompatible polymer or carrier, or pharmaceutically acceptable salts in an amount sufficient to prolong retention and sustain action of the histone deacetylase inhibitor in the mucosa or other tissues of the body to delay onset or decrease severity of the signs and symptoms of mucositis in cancer therapy.
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Accused Products
Abstract
The present invention is directed to methods and compositions of treating or preventing epithelial lining tissue damage from dermatitis or mucositis induced by radiation exposure and/or chemotherapy, by applying to skin, mucosa or other tissues of the body an amount of a therapeutic composition which comprises a histone deacetylase inhibitor formulated with at least one pharmaceutically acceptable biocompatible polymer or carrier, or pharmaceutically acceptable salts in an amount sufficient to delay onset or decrease severity of the signs and symptoms of dermatitis and mucositis in cancer therapy. Such therapeutic compositions have the advantage of prolonged retention and sustained action of the histone deacetylase inhibitor in the skin, mucosa or other tissues of the body. The invention is also directed to treatment and prevention of gastrointestinal distress and cancer-related fatigue syndrome that are associated with mucositis in cancer therapy.
33 Citations
12 Claims
- 1. A method for treating or preventing epithelial lining tissue damage from mucositis induced by radiation exposure and/or chemotherapy, said method comprising applying to mucosa or other tissues of the body an amount of a therapeutic composition which comprises at least one histone deacetylase (HDAC) inhibitor formulated with or without at least one pharmaceutically acceptable biocompatible polymer or carrier, or pharmaceutically acceptable salts in an amount sufficient to prolong retention and sustain action of the histone deacetylase inhibitor in the mucosa or other tissues of the body to delay onset or decrease severity of the signs and symptoms of mucositis in cancer therapy.
- 7. A method for treating or preventing gastrointestinal distress, cancer-related fatigue syndrome and cachexia that are associated with mucositis induced by radiation exposure and/or chemotherapy in cancer therapy, said method comprising applying to mucosa or other tissues of the body an amount of a therapeutic composition which comprises at least one histone deacetylase (HDAC) inhibitor formulated with or without at least one pharmaceutically acceptable biocompatible polymer or carrier, or pharmaceutically acceptable salts in an amount sufficient to prolong retention and sustain action of the histone deacetylase inhibitor in the mucosa or other tissues of the body.
Specification