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Whole genome methylation profiles via single molecule analysis

  • US 20060275806A1
  • Filed: 05/11/2006
  • Published: 12/07/2006
  • Est. Priority Date: 05/11/2005
  • Status: Abandoned Application
First Claim
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1. A method for identifying a methylation profile in an immobilized, elongated polynucleotide, the method comprising the steps of:

  • cleaving the polynucleotide with a methylation-insensitive restriction enzyme;

    imaging the cleaved polynucleotide;

    further cleaving the imaged polynucleotide with a methylation-sensitive restriction enzyme;

    imaging the further cleaved polynucleotide; and

    comparing the images and intramolecular position to reference data to identify the methylation profile in the polynucleotide.

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