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RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)

  • US 20060276635A1
  • Filed: 08/04/2006
  • Published: 12/07/2006
  • Est. Priority Date: 09/05/2002
  • Status: Active Grant
First Claim
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1. A chemically modified double stranded short interfering nucleic acid (siNA) molecule that mediates RNA interference (RNAi) against a mammalian RNA sequence, wherein:

  • a. the siNA comprises a sense strand and an antisense strand;

    b. each strand of the siNA molecule is about 18 to about 27 nucleotides in length;

    c. the antisense strand comprises a nucleotide sequence of about 18 to about 27 nucleotides that is complementary to the mammalian RNA sequence;

    d. the sense strand comprises a portion of about 18 to about 27 nucleotides of the mammalian RNA sequence; and

    e. 100% of the nucleotide positions of the sense strand, the antisense strand, or both the sense strand and antisense strand comprise chemically modified nucleotides.

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