Invasive chemometry
First Claim
1. A method of assessing a component of a tissue of an animal, the method comprising assessing multiple irradiated regions of an animal body to identify at least one region that exhibits a first optical characteristic of the tissue and assessing a second optical characteristic of the component for at least one identified region.
3 Assignments
0 Petitions
Accused Products
Abstract
The invention relates to methods and devices for assessing one or more components of a selected tissue in an animal. The present invention permits non-invasive assessment of tissue components in a body structure containing multiple tissue types by assessing multiple regions of the animal'"'"'s body for an optical characteristic of the tissue of interest and separately assessing one or more optical (e.g., Raman or NIR) characteristics of the tissue component for one or more regions that exhibit the optical characteristic of the tissue of interest.
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Citations
75 Claims
- 1. A method of assessing a component of a tissue of an animal, the method comprising assessing multiple irradiated regions of an animal body to identify at least one region that exhibits a first optical characteristic of the tissue and assessing a second optical characteristic of the component for at least one identified region.
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5-7. -7. (canceled)
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9-10. -10. (canceled)
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13. (canceled)
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15. (canceled)
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17. (canceled)
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20-23. -23. (canceled)
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25-30. -30. (canceled)
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33-34. -34. (canceled)
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36-45. -45. (canceled)
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48-49. -49. (canceled)
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51-52. -52. (canceled)
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53. A device for assessing a component of a tissue of an animal in vivo, the device comprising a first detector for assessing multiple irradiated regions of an animal body to identify at least one region that exhibits a first optical characteristic of the tissue, the first detector being operably linked with a controller for limiting assessment of a second optical characteristic of the component to the identified regions.
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54-73. -73. (canceled)
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74. A device for assessing a component of a tissue of an animal in vivo, the device comprising
a radiation source for irradiating multiple regions of an animal body, light being conveyed from the radiation source to each of the regions by at least one discrete optical illumination fiber for each region; -
a first detector for identifying regions that exhibit a first optical characteristic of the tissue, the first detector being optically coupled with the regions by way of at least one discrete optical detection fiber for each region;
a second detector for assessing Raman-shifted radiation scattered by the identified regions, the second detector being optically coupled with the identified regions by way of at least one discrete optical detection fiber for each region, and there being an optical filter interposed between the second detector and the identified regions and;
a computer processor operably linked to the second detector for restricting assessment of Raman-shifted scattered radiation to the identified regions and for correlating Raman-shifted radiation scattered by the identified regions with the quantity of the component in the tissue.
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75-76. -76. (canceled)
Specification