Devices and methods for percutaneous repair of the mitral valve via the coronary sinus

• US 20060276890A1
• Filed: 06/03/2005
• Published: 12/07/2006
• Est. Priority Date: 06/03/2005
• Status: Active Grant

• Current Assignee: Edwards Lifesciences Corporation
• Original Assignee: Edwards Lifesciences Corporation
• Inventors: Schreck, Stefan, Solem, Jan Otto, Adzich, Vaso, Iancea, Octavian, Kimblad, Per Ola, Fariabi, Sepehr
• Granted Patent: US 7,500,989 B2
• Time in Patent Office: Days
• US Class Current: 623/2.360
• CPC Class Codes: A61F 2/2451 Inserts in the coronary sinus for correcting the valve shape

Abstract

Devices and methods for treating mitral regurgitation by reshaping the mitral annulus in a heart. One preferred device for reshaping the mitral annulus is provided as an elongate body having dimensions as to be insertable into a coronary sinus. The elongate body includes a proximal frame having a proximal anchor and a distal frame having a distal anchor. A ratcheting strip is attached to the distal frame and an accepting member is attached to the proximal frame, wherein the accepting member is adapted for engagement with the ratcheting strip. An actuating member is provided for pulling the ratcheting strip relative to the proximal anchor after deployment in the coronary sinus. In one preferred embodiment, the ratcheting strip is pulled through the proximal anchor for pulling the proximal and distal anchors together, thereby reshaping the mitral annulus.

Claims

1. A device for the treatment of mitral annulus dilatation comprising:

an elongate body having dimensions as to be insertable into a coronary sinus, the elongate body including;

a proximal frame having a proximal anchor, the proximal anchor being transferable between a first state and a second state;

a distal frame having a distal anchor, the distal anchor being transferable between a first state and a second state;

a ratcheting strip attached to the distal frame, the ratcheting strip having alternating engagement portions and openings;

an accepting member attached to the proximal frame, the accepting member insertable into the openings of the ratcheting strip and adapted to engage the engagement portions of the ratcheting strip; and

an actuating member being adapted to engage the ratcheting strip and to move the ratcheting strip relative to the proximal anchor;

wherein the diameters of the proximal anchor and the distal anchor are greater in the second state than in the first state; and

wherein the proximal anchor is adapted to allow the ratcheting strip to be pulled through it.

2. The device of claim 1 wherein the distal frame further comprises a bridge of X-shaped elements, wherein the bridge is more flexible than the ratcheting strip.

3. The device of claim 1 wherein the proximal anchor and the distal anchor are stents.

4. The device of claim 1 wherein the proximal anchor and the distal anchor are baskets.

5. The device of claim 1 wherein the accepting member further includes a latch.

6. The device of claim 5 further comprising a release mechanism, the release mechanism including a release wire attached through a hole in the latch.

7. The device of claim 1 further comprising a guide catheter covering the elongate body.

8. The device of claim 1 wherein the diameters of the proximal anchor and the distal anchor in the second state are about equal to the diameter of the coronary sinus.

9. A device for the treatment of mitral annulus dilatation comprising:

an elongate body having dimensions as to be insertable into a coronary sinus, the elongate body including;

a proximal anchor, the proximal anchor being transferable between a first state and a second state;

a distal anchor, the distal anchor being transferable between a first state and a second state;

a locking shaft attached to the proximal anchor, the locking shaft having alternating engagement portions and openings;

a cinching thread attached to the distal anchor;

a locking pin attached to the cinching thread, the locking pin having a plurality of locking segments insertable into the openings of the locking shaft and adapted to engage the engagement portions of the locking shaft; and

a pull line attached to the locking pin, the pull line adapted to move the locking pin relative to the locking shaft;

wherein the diameters of the proximal anchor and the distal anchor are greater in the second state than in the first state.

10. The device of claim 9 wherein the proximal anchor and the distal anchor are stents.

11. The device of claim 9 wherein the proximal anchor and the distal anchor are baskets.

12. The device of claim 9 wherein the diameters of the proximal anchor and the distal anchor in the second state are about equal to the diameter of the coronary sinus.

13. The device of claim 9 wherein the proximal anchor is adapted to allow the cinching thread to be pulled through it.

14. The device of claim 9 wherein the locking segments are arms.

15. The device of claim 9 wherein the locking segments are spheres.

16. A device for the treatment of mitral annulus dilatation comprising:

an elongate body having dimensions as to be insertable into a coronary sinus, the elongate body including;

a proximal anchor, the proximal anchor being transferable between a first state and a second state;

a distal anchor, the distal anchor being transferable between a first state and a second state;

a housing attached to the proximal anchor, the housing having jaws transferable between a closed state and an open state; and

a cinching suture attached to the distal anchor, the cinching suture having beads spaced thereon;

wherein the diameters of the proximal anchor and the distal anchor are greater in the second state than in the first state;

wherein the jaws are biased to be in the closed state.

17. The device of claim 16 wherein the proximal anchor and the distal anchor are stents.

18. The device of claim 16 wherein the proximal anchor and the distal anchor are baskets.

19. The device of claim 16 wherein the diameters of the proximal anchor and the distal anchor in the second state are about equal to the diameter of the coronary sinus.

20. The device of claim 16 wherein the proximal anchor is adapted to allow the cinching thread to be pulled through it.

21. A method for reducing mitral valve regurgitation comprising:

inserting an elongate body into a coronary sinus, the elongate body comprising;

a proximal frame having a proximal anchor, the proximal anchor being transferable between a first state and a second state;

a distal frame having a distal anchor, the distal anchor being transferable between a first state and a second state;

a ratcheting strip attached to the distal frame, the ratcheting strip having alternating engagement portions and openings;

an accepting member attached to the proximal frame, the accepting member insertable into the openings of the ratcheting strip and adapted to engage the engagement portions; and

an actuating member being adapted to engage the ratcheting strip and to move the ratcheting strip relative to the proximal anchor;

wherein the diameters of the proximal anchor and the distal anchor are greater in the second state than in the first state;

expanding the distal anchor;

expanding the proximal anchor;

moving the distal anchor relative to the proximal anchor by pulling the ratcheting strip toward the proximal anchor using the actuating member.

22. The method of claim 21 wherein the distal anchor and the proximal anchor are expanded by retracting a delivery sheath.