Balloon catheter for delivering therapeutic agents

• US 20060280858A1
• Filed: 08/22/2006
• Published: 12/14/2006
• Est. Priority Date: 01/05/2001
• Status: Active Grant

• Current Assignee: Lyudmila Kokish
• Original Assignee: Lyudmila Kokish
• Inventors: Kokish, Lyudmila
• Granted Patent: US 7,658,966 B2
• Time in Patent Office: Days
• US Class Current: 427/2.100
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/146 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 2025/1086 having a special balloon surface topography, e.g. pores, protuberances, spikes or grooves
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00

Abstract

A drug delivery device for delivering therapeutic agents and a method of making such a device is disclosed. The device includes an inflatable balloon having a plurality of holes formed in the wall of the balloon. A microporous coating covers a portion of the outer surface of the wall of the balloon. The thickness of the coating and the size of the micropores can permit controlled delivery of a substance from the micropores of the coating and into the tissue of a patient'"'"'s lumen.

Claims

1. A method of coating a drug delivery device, comprising:

applying a composition onto a surface of an inflatable balloon integrated with a catheter, the balloon having a plurality of holes for delivering a drug to a body vessel and the composition including a polymer mixed with a first fluid;

applying a second fluid to the composition on the surface of the balloon, wherein the second fluid is a poorer solvent for the polymer than the first fluid, and wherein the second fluid evaporates less rapidly than the first fluid; and

removing the first and second fluids to form a porous precipitate coating.

2. The method of claim 1, wherein the porous precipitate coating covers at least a portion of the holes and has pores of a size that permit controlled delivery of a drug from the balloon to the body vessel.

3. The method of claim 2, wherein the size of the pores is in a range from approximately 0.001 mm to 0.020 mm.

4. The method of claim 1, wherein a thickness of the porous precipitate coating is in a range from approximately 0.005 mm to 0.020 mm.

5. The method of claim 1, wherein the polymer is selected from the group consisting of silicones, polyesters and polyurethanes.

6. The method of claim 1, wherein the first fluid is selected from the group consisting of tetrahydrofuran, dimethylacetamide, dimethylformamide, dimethylsulfoxide and dioxane.

7. The method of claim 1, wherein the drug is selected from the group consisting of antithrombotics, antiproliferatives, anti-inflammatory agents, smooth muscle cell migration inhibitors, reendothelialization agents and restenosis-reducing drugs.