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Methods for detecting genetic haplotypes by interaction with probes

  • US 20060281102A1
  • Filed: 02/09/2006
  • Published: 12/14/2006
  • Est. Priority Date: 10/24/2001
  • Status: Abandoned Application
First Claim
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1. A method for determining genetic haplotype comprising:

  • (a) identifying a target nucleic acid molecule or gene fragment, said nucleic acid molecule or gene fragment comprising a haplotype of interest, by;

    (i) hybridizing a primer recognizing a first genetic variant, said variant correlating to a haplotype, to the target nucleic acid molecule or gene fragment and wherein a labeled primer dependent transcript is generated from the target nucleic acid or gene fragment; and

    (1) hybridizing at least one labeled probe, said probe recognizing a second genetic variant downstream from the primer, to the primer dependent transcript, or (2) hybridizing at least one unlabeled probe, said probe recognizing recognizing a second genetic variant downstream from the primer, to the primer dependent transcript; and

    (b) detecting at least one parameter displayed by one of the primer-dependent transcript, the at least one probe, or a primer-dependent transcript/probe complex, thereby correlating the displayed parameter to the haplotype.

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