Novel anti-feline albumin antibodies and methods of detecting early renal disease
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Abstract
The present invention provides isolated monoclonal antibodies that selectively bind albumin from animals. Also provided are methods using such antibodies for the detection of early renal disease in animals. The method includes the steps of (a) obtaining a sample from an animal to be tested; (b) contacting the sample with an antibody having a greater avidity for feline albumin than for other proteins or components in the sample; (c) detecting the complex formed by the antibody and albumin; and (d) determining the amount of albumin in the sample from the amount of antibody-albumin complex detected. An amount of albumin in the range of from 10 μg/ml to about 300 μg/ml indicates the presence of early renal disease.
17 Citations
37 Claims
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1-17. -17. (canceled)
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18. A method to detect early renal disease in a felid or canid, said method comprising:
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(a) obtaining a sample from said felid or canid;
(b) contacting the sample with an albumin-binding compound;
(c) detecting the complex formed by the albumin-binding compound and albumin; and
(d) determining the amount of albumin present in the sample from the amount of complex detected, wherein an amount of albumin in a range of from about 10 μ
g/ml to about 300 μ
g/ml in the sample, when the specific gravity of the sample is normalized to 1.010, is indicative of early renal disease. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25)
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26. A method to identify a felid or canid at risk for developing late-stage renal disease, said method comprising:
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(a) obtaining a sample from said felid or canid;
(b) contacting the sample with an albumin-binding compound that has a greater avidity for feline or canid albumin than for other proteins or components in the sample;
(c) detecting the complex formed by the albumin-binding compound and albumin; and
(d) determining the amount of albumin present in the sample from the amount of complex detected, wherein an amount of albumin in a range of from about 10 μ
g/ml to about 300 μ
g/ml in the sample, when the specific gravity of the sample is normalized to 1.010, indicates said felid or canid is at risk for developing late-stage renal disease. - View Dependent Claims (27, 28, 29, 30, 31)
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- 32. An isolated monoclonal antibody that selectively binds albumin from a felid or canid.
Specification