Analyte detection devices and methods with hematocrit/volume correction and feedback control
First Claim
1. An arrangement for measuring the concentration of an analyte contained in a sample of body fluid, the arrangement comprising:
- an assay pad comprising at least one chemical reagent capable of producing a detectable signal in the form of a reaction spot formed upon reaction with the analyte;
a light source;
a detector array;
a processor; and
a memory in communication with the processor, the memory comprising;
(a) at least one value indicative of one or more of;
(i) the level of hematocrit contained in the sample;
(ii) the volume of the sample applied to the assay pad;
or (iii) imperfections present in the reaction spot; and
(b) at least one algorithm for calculating the concentration of the analyte contained in the sample.
2 Assignments
0 Petitions
Accused Products
Abstract
Disclosed are devices, arrangements and methods for quantifying the concentration of an analyte present in bodily fluid, including: an assay pad having at least one chemical reagent capable of producing a detectable signal in the form of a reaction spot upon reaction with the analyte; a light source; a detector array; a processor; and a memory in communication with the processor, the memory comprising: (a) at least one value indicative of one or more of: (i) the level of hematocrit contained in the sample; (ii) the volume of the sample applied to the assay pad; or (iii) imperfections present in the reaction spot; and (b) at least one algorithm for calculating the concentration of the analyte contained in the sample.
197 Citations
36 Claims
-
1. An arrangement for measuring the concentration of an analyte contained in a sample of body fluid, the arrangement comprising:
-
an assay pad comprising at least one chemical reagent capable of producing a detectable signal in the form of a reaction spot formed upon reaction with the analyte;
a light source;
a detector array;
a processor; and
a memory in communication with the processor, the memory comprising;
(a) at least one value indicative of one or more of;
(i) the level of hematocrit contained in the sample;
(ii) the volume of the sample applied to the assay pad;
or(iii) imperfections present in the reaction spot; and
(b) at least one algorithm for calculating the concentration of the analyte contained in the sample. - View Dependent Claims (2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 35)
-
-
7. The arrangement of claim δ
- , wherein the at least one catalyst device comprises at least one of a vacuum pump, a vibration motor and a heating element.
-
16. A method of measuring the content of analyte contained in a sample of body fluid, the method comprising:
-
providing an assay pad comprising at least one chemical reagent;
introducing a sample onto the assay pad;
producing a detectable signal in the form of a reaction spot formed upon reaction of the at least one chemical reagent with the analyte;
generating a signal based on light reflected off the assay pad;
calculating at least one value indicative to one or more of;
(i) the level of hematocrit contained in the sample;
(ii) the volume of the sample applied to the assay pad;
or(iii) imperfections present in the reaction spot; and
calculating the concentration of analyte contained in the sample by factoring in the at least one value. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
-
-
28. An arrangement for measuring the concentration of an analyte contained in a sample of body fluid, the arrangement comprising:
-
an assay pad comprising at least one chemical reagent capable of producing a detectable signal in the form of a reaction spot formed upon reaction with the analyte;
a light source;
a detector array;
a processor;
a memory in communication with the processor; and
at least one catalyst device constructed and arranged to be responsive to control signals. - View Dependent Claims (29, 30, 31, 32, 33, 34, 36)
-
Specification