Foamable alcohol compositions, systems and methods of use

• US 20060281663A1
• Filed: 06/13/2005
• Published: 12/14/2006
• Est. Priority Date: 06/13/2005
• Status: Active Grant

• Current Assignee: Solventum Intellectual Properties Company (Solventum Corp.)
• Original Assignee: 3M Innovative Properties Company (3M Company)
• Inventors: Asmus, Robert A.
• Granted Patent: US 7,651,990 B2
• Time in Patent Office: Days
• US Class Current: 510/511
• CPC Class Codes: A61K 8/34 Alcohols
• CPC Class Codes: A61K 8/731 Cellulose; Quaternized cellulose derivatives
• CPC Class Codes: A61K 8/86 Polyethers
• CPC Class Codes: A61K 8/894 modified by a polyoxyalkylene group, e.g. cetyl dimethicone copolyol
• CPC Class Codes: A61P 31/02 Local antiseptics
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: C11D 1/82 Compounds containing silicon
• CPC Class Codes: C11D 3/0094 High foaming compositions
• CPC Class Codes: C11D 3/2006 Monohydric alcohols
• CPC Class Codes: C11D 3/201 linear
• CPC Class Codes: C11D 3/225 etherified, e.g. CMC
• CPC Class Codes: C11D 3/3707 Polyethers, e.g. polyalkyleneoxides
• CPC Class Codes: C11D 3/48 Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

Abstract

A composition, systems for dispensing the composition and methods for the use of the composition are described. The composition comprises: (A) Monohydric alcohol in an amount sufficient to provide antimicrobial activity; (B) Surfactant comprising a dimethicone surfactant; and (C) Builder, the builder in an amount sufficient to provide stability or to improve the stability of a foam formed from the composition.

Claims

1. A composition, comprising:

(A) Monohydric alcohol in an amount sufficient to provide antimicrobial activity;

(B) Surfactant comprising a dimethicone surfactant; and

(C) Builder, the builder in an amount sufficient to provide stability or to improve the stability of a foam formed from the composition.

2. The composition as defined in claim 1, wherein the monohydric alcohol is selected from the group consisting of ethanol, propanol, butanol and combinations of two or more of the foregoing.

3. The composition as defined in claim 2, wherein the monohydric alcohol is present in the composition at a concentration from about 35% to about 99.5% by weight.

4. The composition as defined in claim 2, wherein the monohydric alcohol is present in the composition at a concentration from about 60% to about 80% by weight.

5. The composition as defined in claim 1, wherein the surfactant is present in the composition at a concentration from about 0.1% to about 10% by weight.

6. The composition as defined in claim 1, wherein the surfactant is present in the composition at a concentration from about 0.5% to about 5% by weight.

7. The composition as defined in claim 1, wherein the dimethicone surfactant is selected from hydroxy-terminated dimethicone copolyol, methoxy-terminated dimethicone copolyol, butoxy-terminated dimethicone copolyol, or combination of two or more of the foregoing.

8. The composition as defined in claim 7, wherein the molar ratio of poly(ethylene oxide) to poly(propylene oxide) ranges from about 0/50 to about 50/0 and the molecular weight of the dimethicone portion of the dimethicone surfactant ranges from about 200 to about 20,000.

9. The composition as defined in claim 1, wherein the dimethicone surfactant is selected from the group consisting of methoxy-terminated polyethylene glycol dimethicone having an average molecular weight of about 3000;

dimethicone with a pendant ether of 35/65 (w/w) polyethylene glycol/polypropylene glycol copolymer having a combined average molecular weight of about 7,000;

dimethicone copolyol with 18/18 (molar ratio) polyethylene glycol/polypropylene glycol;

dimethicone copolyol with 17/18 (molar ratio) polyethylene glycol/polypropylene glycol;

dimethicone copolyol with polyethylene glycol/polypropylene glycol-methoxy terminated having an average molecular weight of about 20,000 and a hydrophile-liphophile balance of 9-12;

dimethicone copolyol with a methoxy-terminated polyethylene glycol having a combined average molecular weight of about 3000;

dimethicone copolyol with a methoxy-terminated polyethylene glycol having a combined average molecular weight of about 6000;

dimethicone copolyol with a hydroxy terminated polyethylene glycol having a combined average molecular weight of about 5000 with a hydrophile-liphophile balance of 13-17;

dimethicone copolyol lactate;

silicone copolyol pelargonate;

hydroxyl-capped dimethicone copolyol;

hydroxyl-terminated polyethylene glycol-12 dimethicone;

dimethicone copolyol laurate;

Silicone Quaternary 1;

hydroxy-terminated polyethylene glycol dimethicone having an average molecular weight of about 4000;

methoxy-terminated polyethylene glycol dimethicone having an average molecular weight of about 600;

Silicone Quaternary 2 (Myristyl);

sodium dimethicone copolyol acetyl methyltaurate;

butoxy-terminated poly(propylene oxide)dimethicone having an average molecular weight of about 3,000;

silicone copolyol isostearate; and

combinations of two or more of the foregoing.

10. The composition as defined in claim 1 wherein the dimethicone surfactant is selected from the group consisting of dimethicone bisamino hydroxypropyl copolyol, dimethicone copolyol acetate, dimethicone copolyol adipate, dimethicone copolyol almondate, dimethicone copolyolamine, dimethicone copolyol avocadoate, dimethicone copolyol beeswax, dimethicone copolyol behenate, dimethicone copolyol benzoate, dimethicone copolyol bishydroxy ethylamine, dimethicone copolyol borageate, dimethicone copolyol butyl ether, dimethicone copolyol cocoa butterate, dimethicone copolyol crosspolymer, dimethicone copolyol dhupa butterate, dimethicone copolyol ethyl ether, dimethicone copolyol hydroxy stearate, dimethicone copolyol isostearate, dimethicone copolyol kokum butterate, dimethicone copolyol lactate, dimethicone copolyol laurate, dimethicone copolyol mango butterate, dimethicone copolyol meadowfoamate, dimethicone copolyol methyl ether, dimethicone copolyol mohwa butterate, dimethicone copolyol octyldodecyl citrate, dimethicone copolyol olivate, dimethicone copolyol phosphate, dimethicone copolyol phthalate, dimethicone copolyol sal butterate, dimethicone copolyol shea butterate, dimethicone copolyol stearate, dimethicone copolyol undecylenate, dimethicone hydroxypropyl trimonium chloride, dimethicone propyl pg-betaine, polysilicone-10, polysilicone-8, dimethicone propylethylenediamine behenate, amino bispropyl dimethicone aminoethylaminopropyl dimethicone, behentrimonium dimethicone copolyol phthalate, bis-aminopropyl copolyol aminopropyl dimethicone, bis-hydroxyethoxypropyl dimethicone, cetyl triethylmonium dimethicone copolyol succinate, dimethicone copolyol sulfate, dimethicone copolyol phosphate, dimethicone polyglycerol, disodium copolyol dimethicone sulfosuccinate, copolyol polydimethylsiloxyethyl dimethicone, copolyol pg-coco-glucoside dimethicone, copolyol nonafluorohexyl dimethicone copolymer, copolyol methyl ether lauroxy peg amidopropyl dimethicone, copolyol oleyl ether dimethicone, sodium carboxydecyl copolyol dimethicone and combinations of two or more of the foregoing.

11. The composition as defined in claim 1, wherein the dimethicone surfactant comprises a molar ratio of polyethylene glycol to polypropylene glycol of about 18/18.

12. The composition as defined in claim 1 wherein the builder is selected from the group consisting of poly(ethylene oxide) having a molecular weight in the range from about 100,000 to 10,000,000, polyethylene-polypropylene copolymer, hydroxyethyl cellulose, hydroxypropyl cellulose and combinations of two or more of the foregoing.

13. The composition as defined in claim 12 wherein the builder is present in the composition at a concentration between about 0.001% and about 5% by weight.

14. The composition as defined in claim 12, wherein the builder comprises poly(ethylene oxide) having an average molecular weight in the range from about 200,000 to about 4,000,000.

15. The composition as defined in claim 14 wherein the builder is present in the composition at a concentration less than or equal to about 0.1% by weight.

16. The composition as defined in claim 14 wherein the builder is present in the composition at a concentration of about 0.06% by weight.

17. The composition as defined in claim 1 wherein the builder is swellable within the alcohol.

18. The composition as defined in claim 1 wherein the builder is dispersible in the alcohol.

19. The composition as defined in claim 1 wherein the builder is soluble in the alcohol.

20. The composition as defined in claim 1 wherein the builder is selected from the group consisting of hydroxypropyl guar, polyquaternium-4, polyquaternium-10, cetyl hydroxyethylcellulose, ethylhydroxy ethyl cellulose, polyglycerol, high molecular wt. polyoxamer, high molecular wt. polyoxamine, polyacrylamide, high molecular wt polyethylene glycol esters and ethers with alkyl alcohols or acid functional alkyls, polyacrylamidomethylpropane sulfonic acid, polyacrylic acid, polyethylene/isopropyl maleate/malaic acid copolyol, polymethacrylamidopropyltrimonium chloride, polymethacrylamidopropyltrimonium methosulfate, polymethacrylic acid, polyquaternium-1 to polyquaternium-47, polyvinyl methyl ether, butylated poly vinyl pyrrolidone, hydroxypropyl methylcellulose;

hydroxypropyl cellulose;

crosslinked and non-crosslinked homopolymer or crosslinked and non-crosslinked copolymer containing n-vinyl lactam monomeric units and combinations of two or more of the foregoing.

21. The composition as defined in claim 1, further comprising an emollient wherein the emollient is present in the composition at a concentration of about 30% by weight or less.

22. The composition as defined in claim 1, further comprising a secondary antimicrobial agent, the secondary antimicrobial agent present in the composition at a concentration up to about 10% by weight.

23. The composition as defined in claim 22 wherein the secondary antimicrobial agent is selected from the group consisting of parachlorometaxylenol;

triclosan;

chlorhexidine and its salts, poly hexamethylene biguanide and its salts, iodine, idodophors;

fatty acid monoesters;

poly-n-vinyl pyrrolidone-iodophors;

silver oxide, silver and its salts, peroxides, antibiotics, and combinations of two or more of the foregoing.

24. The composition as defined in claim 22 wherein the secondary antimicrobial agent is benzoyl peroxide.

25. The composition as defined in claim 1, further comprising one or more skin barrier materials in an amount from about 0.1% to 60% by weight.

26. The composition as defined in claim 25, wherein the barrier material is selected from the group consisting of aldioxa, allantoin, aluminum acetate, aluminum hydroxide, bismuth subnitrate, boric acid, calamine, cellulose, cholecalciferol, cocoa butter, cod liver oil, colloidal oatmeal, cysteine hydrochloride, dexpanthenol, dimethicone, glycerin kaolin, lanolin, live yeast cell derivative, mineral oil, peruvian balsam, peruvian balsam oil, pertrolatum, protein hydrolysate, racemethionine, shark liver oil, sodium bicarbonate, sulfur, talc, tannic acid, topical starch, vitamin A, white petrolatum, zinc acetate, zinc carbonate, zinc oxide and combinations of two or more of the foregoing.

27. The composition as defined in claim 1, further comprising an antifungal agent.

28. The composition as defined in claim 1, wherein the viscosity of the composition prior to foaming at 23°

C. is within the range from about 0.5 to about 100 cps.

29. The composition as defined in claim 1, wherein the viscosity of the composition prior to foaming at 23°

C. is within the range from about 0.5 cps to about 50 cps.

30. The composition as defined in claim 1, wherein the viscosity of the composition prior to foaming at 23°

C. is within the range from about 0.5 cps to about 20 cps.

31. The composition as defined in claim 1, further comprising a propellant selected from the group consisting of chlorofluorocarbons, hydrochlorofluorocarbons, hydrofluorocarbons, perfluorinated alkanes, lower alkanes having a carbon chain length of C₁-C₅, nitrous oxide dimethyl ether and combinations of two or more of the foregoing.

32. A system comprising a container and the composition as defined in claim 31, the composition contained within the container under pressure and the propellant being present within the composition at a concentration from about 2% to about 30% by volume.

33. A system comprising:

A dispenser comprising a reservoir and a hand pump; and

The composition of claim 1 contained within the reservoir.

34. A skin sanitizer comprising the composition of claim 1.

35. A pre-surgical hand scrub comprising the composition of claim 1.

36. A method for sanitizing a surface, comprising:

Applying a volume of the composition of claim 1 to the surface, the composition being in the form of a stable foam.

37. The method as defined in claim 36, wherein the surface is human skin.

38. The method as defined in claim 37, wherein a discrete volume of stable foam is applied to the surface of the skin and subsequently spread out across the surface of the skin.

39. The method as defined in claim 38, further comprising rinsing the surface of the skin with water.