Pharmaceutical composition for the management of tumors
First Claim
1. A pharmaceutical composition for the management of tumors comprising salt of glucaric acid, salt of nicotinaminio acid, and butyric acid either in combination of any two or all of three compounds along with pharmaceutically acceptable excipients, diluents or carriers.
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Abstract
The present invention relates to the effect of naturally occurring compounds on tumor development. As an example of proof, we used low; non-toxic doses of three compound e.g. Calcium D-glucarate, a naturally occurring Ca++ salt of D-glucaric acid; Nicotinamide (NA), a naturally occurring vitamin and butyric acid (BA), a naturally occurring saturated short chain fatty acid. 7,12 dimethylbenzanthracene (DMBA), which is a very potent skin carcinogen and is an environmental pollutant, was used for skin tumor development. Experiment was performed upto 30 weeks. All the above-mentioned compounds were used either alone or concomitantly any two or all the three. In the positive control group 100% tumorigenesis was attained in 28 weeks, use of single compound led to the inhibition of DMBA induced tumorigenesis between 33 to 47%, use of two compounds resulted in the 73 to 80% reduction in tumorigenesis but the concomitant use of three compounds resulted into 100% inhibition of tumor development at the end of 30 weeks. This led us to conclude that the concomitant use of Cag, NA and BA in combination of two is useful for preventing skin tumor develoment for a sort or long period of time. But the concomitant use of all the three compounds, as described, exhibited the perfect synergistic effect in preventing the tumor development completely. This strategy should be equally effective in the management of benign and possibly malignant tumor in any organ caused by any mean.
18 Citations
30 Claims
- 1. A pharmaceutical composition for the management of tumors comprising salt of glucaric acid, salt of nicotinaminio acid, and butyric acid either in combination of any two or all of three compounds along with pharmaceutically acceptable excipients, diluents or carriers.
- 11. Use of the pharmaceutical composition for the management of tumors comprising salt of glucaric acid, salt of nicotinamide acid, and butyric acid either in combination of two or all of three compounds along with pharmaceutically acceptable excipients, diluents or carriers.
- 21. A method for the management of tumors comprising administering to a subject suffering therefrom, a pharmaceutically effective amount of a pharmaceutical composition comprising salt of glucaric acid, salt of nicotinaminic acid, and butyric acid either in combination of two or all of three compounds along with pharmaceutically acceptable excipients, diluents or carriers.
Specification