Local Delivery of Rapamycin for Treatment of Proliferative Sequelae Associated with PTCA Procedures, Including Delivery Using a Modified Stent
First Claim
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1. A metallic stent having a coating applied thereto, wherein:
- said coating comprises a mixture of a biocompatible polymeric carrier and a therapeutic agent;
said polymeric carrier comprises at least one nonabsorbable polymer;
said therapeutic agent is rapamycin, or a macrocyclic lactone analog thereof, present in an amount effective to inhibit neointimal proliferation; and
said device provides a controlled release of said therapeutic agent over a period of several weeks.
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Abstract
Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-based polymeric coating facilitates the performance of such devices in inhibiting restenosis.
22 Citations
5 Claims
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1. A metallic stent having a coating applied thereto, wherein:
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said coating comprises a mixture of a biocompatible polymeric carrier and a therapeutic agent;
said polymeric carrier comprises at least one nonabsorbable polymer;
said therapeutic agent is rapamycin, or a macrocyclic lactone analog thereof, present in an amount effective to inhibit neointimal proliferation; and
said device provides a controlled release of said therapeutic agent over a period of several weeks. - View Dependent Claims (2, 3, 4, 5)
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Specification