Method of making recombinant human antibodies for use in biosensor technology
First Claim
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1. A method for detecting the presence of at least one biological agent of interest in a sample, said method comprising:
- (a) combining said sample with a composition comprising a population of biosensor antibodies, wherein i. said biosensor antibodies are bound to a solid support;
ii. the population of said biosensor antibodies comprises antibodies directed to at least one biological agent of interest in said sample;
(b) capturing any biological agents of interest;
(c) identifying any biological agents of interest present in said sample; and
, (d) reporting the capture of said at least one biological agent of interest.
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Abstract
According to the current invention and apparatus and methods are provided for the production of modified antibodies and calins for use in biosensor applications.
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Citations
93 Claims
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1. A method for detecting the presence of at least one biological agent of interest in a sample, said method comprising:
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(a) combining said sample with a composition comprising a population of biosensor antibodies, wherein i. said biosensor antibodies are bound to a solid support;
ii. the population of said biosensor antibodies comprises antibodies directed to at least one biological agent of interest in said sample;
(b) capturing any biological agents of interest;
(c) identifying any biological agents of interest present in said sample; and
,(d) reporting the capture of said at least one biological agent of interest. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 90)
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43. A biosensor apparatus for detecting the presence of at least one biological agent of interest in a sample, said apparatus comprising:
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(a) means for taking a sample and thereafter combining said sample with a composition comprising a population of biosensor antibodies, wherein i. said biosensor antibodies are bound to a solid support;
ii. the population of said biosensor antibodies comprises antibodies directed to at least one biological agent of interest in said sample;
(b) means for capturing any biological agents of interest;
(c) means for identifying any biological agents of interest present in said sample; and
,(d) means for reporting the capture of said at least one biological agent of interest. - View Dependent Claims (44, 45, 46, 47, 48, 49, 50, 51, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 91)
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52. The apparatus according to ciaim 43, wherein said population of biosensor antibodies represents at least ten discrete subpopulations each directed towards the detection of a different biological agent.
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92. A method for detecting the presence of at least one biological agent of interest in a sample, said method comprising:
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(a) combining said sample with a composition comprising a population of biosensor calins, wherein i. said biosensor calins are bound to a solid support;
ii. the population of said biosensor calins comprises calins directed to at least one biological agent of interest in said sample;
(c) identifying any biological agents of interest present in said sample; and
,(d) reporting the capture of said at least one biological agent of interest.
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93. An apparatus for detecting the presence of at least one biological agent of interest in a sample, said method comprising:
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(a) combining said sample with a composition comprising a population of biosensor calins, wherein i. said biosensor calins are bound to a solid support;
ii. the population of said biosensor calins comprises calins directed to at least one biological agent of interest in said sample;
(b) capturing any biological agents of interest;
(c) identifying any biological agents of interest present in said sample; and
,(d) reporting the capture of said at least one biological agent of interest.
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Specification