Method of use of antagonists of zonulin to prevent the loss of or to regenerate pancreatic cells
First Claim
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1. A method of slowing the loss of pancreatic β
- -cells in a subject in need thereof, comprising;
administering to the subject a composition comprising an antagonist of zonulin.
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Abstract
The present invention provides materials and methods for the treatment of diabetes. Using the materials and methods of the invention, the loss of pancreatic β-cells can be slowed and/or prevented. In addition, the materials and methods of the invention can be used to regenerate pancreatic β-cells.
20 Citations
35 Claims
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1. A method of slowing the loss of pancreatic β
- -cells in a subject in need thereof, comprising;
administering to the subject a composition comprising an antagonist of zonulin. - View Dependent Claims (2, 3, 4)
- -cells in a subject in need thereof, comprising;
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5. A method of regenerating pancreatic β
- -cells in a subject in need thereof, comprising;
administering to the subject a zonulin antagonist and a cell. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12, 13)
- -cells in a subject in need thereof, comprising;
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14. A method of regenerating pancreatic β
- -cells in a subject in need thereof, comprising;
administering to the subject a zonulin antagonist under conditions permitting replication of β
-cells. - View Dependent Claims (15, 16, 17)
- -cells in a subject in need thereof, comprising;
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18. A method of regenerating pancreatic β
- -cells in a subject in need thereof, comprising;
administering to the subject a zonulin antagonist; and
implanting cells into the subject. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
- -cells in a subject in need thereof, comprising;
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31. A method of treating an autoimmune disease, comprising:
administering a compound that prevents an increase in permeability of an anatomical barrier. - View Dependent Claims (32, 33, 34, 35)
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