DEVICE AND METHOD FOR INHIBITING RELEASE OF PRO-INFLAMMATORY MEDIATOR
First Claim
1. A method for inhibiting release of a proinflammatory mediator from a mammalian cell, the method comprising:
- identifying a mammalian subject suffering from, or at risk for, a disease or disorder mediated by a proinflammatory mediator; and
applying a stimulation signal to the subject in an amount effective to inhibit the release of the proinflammatory mediator, wherein the stimulation signal is applied to a splenic nerve, splenic neurovascular bundle, a periarterial splenic nerve, splenic peritoneum, splenic tissue, celiac plexus surrounding the celiac artery, celiac ganglia, aorticorenal ganglia, greater thoracic splanchnic nerves, lesser thoracic splanchnic nerves, least thoracic splanchinc nerves or a combination thereof.
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Abstract
Stimulation of one or more neurons of the sympathetic nervous system, including the splenic nerve, to attenuate an immune response, including an inflammatory immune response, is discussed. Devices and systems to stimulate the sympathetic nervous system to attenuate an immune response are also discussed. Devices discussed include pulse generators and drug pumps. Systems are described as optionally having one or more sensors and operator instructions. In specific examples, stimulation of the splenic nerve of pigs with a pulse generator is shown to be safe and effective in attenuating a lipopolysaccharide-induced immune response.
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Citations
21 Claims
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1. A method for inhibiting release of a proinflammatory mediator from a mammalian cell, the method comprising:
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identifying a mammalian subject suffering from, or at risk for, a disease or disorder mediated by a proinflammatory mediator; and
applying a stimulation signal to the subject in an amount effective to inhibit the release of the proinflammatory mediator, wherein the stimulation signal is applied to a splenic nerve, splenic neurovascular bundle, a periarterial splenic nerve, splenic peritoneum, splenic tissue, celiac plexus surrounding the celiac artery, celiac ganglia, aorticorenal ganglia, greater thoracic splanchnic nerves, lesser thoracic splanchnic nerves, least thoracic splanchinc nerves or a combination thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification