Epoxy Enhanced Polymer Membrane to Increase Durability of Biosensors
First Claim
1. A coating for an implantable biosensor comprising an epoxy polymer membrane, the epoxy polymer membrane comprising an epoxy resin adhesive and a polymer whereby the epoxy polymer membrane increases the durability of the biosensor.
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Abstract
The present invention provides a polymer membrane enhanced with cured epoxy resin for use as the outer membrane of biosensors. The membrane includes approximately 30-80% epoxy resin adhesives, 10-60% polymer such as poly(vinyl chloride), polycarbonate and polyurethane and 0-30% plasticizers and 5-15% surface modifier reagent such as polyethylene oxide-containing block copolymers. Utilizing the polymer membrane of the present invention, a three-layered sensing element has been developed. This sensing element will be particularly useful for miniaturized biosensors used for in vitro blood measurements or for continuous in vivo monitoring such as implantable biosensors. This element includes an enzyme layer, an interference-eliminating layer and the novel polymer member of the present invention as the outer polymer layer. This novel sensing element shows excellent response characteristics in solutions and has an extremely long lifetime. This technology is particularly useful for improving the lifetime of implantable biosensors.
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Citations
24 Claims
- 1. A coating for an implantable biosensor comprising an epoxy polymer membrane, the epoxy polymer membrane comprising an epoxy resin adhesive and a polymer whereby the epoxy polymer membrane increases the durability of the biosensor.
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11. A multilayered sensing element for biosensors comprising:
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an immobilized enzyme layer formed on an electrode surface; and
an epoxy polymer layer external to the immobilized enzyme layer. - View Dependent Claims (12, 13, 14, 15, 16, 17)
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18. A multilayered coil-type implantable glucose sensor comprising:
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an immobilized glucose oxidase enzyme layer adjacent to the surface of a coiled wire; and
an epoxy polymer layer;
the epoxy polymer layer external to the immobilized glucose oxidase enzyme layer. - View Dependent Claims (19, 20, 21, 22, 23, 24)
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Specification