ANTIMICROBIAL COMPOSITION

• US 20060292086A1
• Filed: 06/27/2006
• Published: 12/28/2006
• Est. Priority Date: 06/27/2005
• Status: Active Grant

• Current Assignee: Pilot Chemical Corp.
• Original Assignee: Mason Chemical Company (Pilot Chemical Corp.)
• Inventors: CURTIS, Michael A.
• Granted Patent: US 7,754,770 B2
• Time in Patent Office: Days
• US Class Current: 424/47
• CPC Class Codes: A61K 31/14 Quaternary ammonium compounds, e.g. edrophonium, choline betaines A61K31/205
• CPC Class Codes: A61K 8/046 Aerosols; Foams
• CPC Class Codes: A61K 8/416 Quaternary ammonium compounds A61K8/35 takes precedence
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations

Abstract

An antimicrobial composition is provided. The antimicrobial composition has broad antimicrobial efficacy in a format convenient for no-rinse application to the skin. The composition dries quickly, leaves the skin smooth, comfortable and adequately moisturized. A method of making the antimicrobial composition, a method of sanitizing skin using the antimicrobial composition, and a foam dispenser comprising the antimicrobial composition are also provided.

Claims

1. An antimicrobial composition comprising:

(a) an antimicrobial agent, wherein the anti-microbial agent is selected from the group consisting of benzalkonium chloride and benzethonium chloride;

(b) a foaming agent, wherein the foaming agent is selected from the group consisting of dihydroxypropyl PEG-5 linoleammonium chloride, cocamidopropyl betaine, PEG-15 cocomonium chloride, and PEG-6 cocamide;

(c) a stabilizer, wherein the stabilizer is selected from the group consisting of dihydroxyethyl cocamine oxide, cocamide DEA, cocamidopropylamine oxide, cocamine oxide, lauramine oxide, and myristamine oxide; and

(d) a conditioning agent, wherein the conditioning agent is selected from the group consisting of behentrimonium chloride, cetrimonium chloride, stearalkonium chloride, and behenoyl PG-trimonium chloride, wherein the composition does not contain alcohol.

2. The antimicrobial composition of claim 1, wherein the composition does not contain a silicone or a polymer thickener.

3. The antimicrobial composition of claim 1, further comprising an emollient.

4. The antimicrobial composition of claim 1, comprising:

(a) from approximately 0.1% to approximately 0.13% benzalkonium chtoride

(b) from approximately 0.05% to approximately 0.5% dihydroxypropyl PEG-5 linoleammonium chloride;

(c) from approximately 0.05% to approximately 0.5% dihydroxyethyl cocamine oxide

(d) from approximately 0.05% to approximately 0.5% glycereth-2 cocoate; and

(e) from approximately 0.05% to approximately 0.5% behentrimonium chloride.

5. The antimicrobial composition of claim 1, comprising:

(a) approximately 0.1% benzalkonium chloride

(b) approximately 0.3% dihydroxypropyl PEG-5 linoleammonium chloride

(c) approximately 0.1% dihydroxyethyl cocamine oxide

(d) approximately 0.1% glycereth-2 cocoate, and

(e) approximately 0.1% behentrimonium chloride.

6. The antimicrobial composition of claim 4, wherein the benzalkonium chloride is a homolog having the following formula:

7. The antimicrobial composition of claim 5, wherein the benzalkonium chloride is a homolog having the following formula:

8. The antimicrobial composition of claim 6, wherein the homolog distribution is not less than 40% C₁₂, not less than 20% C₁₄, and not less than 70% C₁₂ and C₁₄ combined.

9. The antimicrobial composition of claim 7, wherein the homolog distribution is not less than 40% C₁₂, not less than 20% C₁₄, and not less than 70% C₁₂ and C₁₄ combined.

10. The antimicrobial composition of claim 6, wherein the homolog distribution is less than 90%, less than 85%, less than 80%, or less than 75% combined C₁₂ and C₁₄ homologs.

11. The antimicrobial composition of claim 7, wherein the homolog distribution is less than 90%, less than 85%, less than 80%, or less than 75% combined C₁₂ and C₁₄ homologs.

12. The antimicrobial composition of claim 6, wherein the homolog distribution is approximately 67% C₁₂, approximately 25% C₁₄, approximately 7% C₁₆, and 1% C₁₈.

13. The antimicrobial composition of claim 7, wherein the homolog distribution is approximately 67% C₁₂, approximately 25% C₁₄, approximately 7% C₁₆, and 1% C₁₈.

14. The antimicrobial composition of claim 1, wherein the skin sanitizer al inactivates greater than 90% of a microbe, greater than 95% of a microbe, greater than 96% of a microbe, greater than 97% of a microbe, greater than 98% of a microbe, greater than 99% of a microbe, or greater than 99.9% of a microbe, within approximately 15 seconds from the time of application to an area containing microbes.

15. The antimicrobial composition of claim 1, wherein the microbe is inactivated within approximately 12 seconds from the time of application, within approximately 10 seconds from the time of application, within approximately 7 seconds from the time of application, within approximately 5 seconds from the time of application, within approximately 3 seconds from the time of application, within approximately 2 seconds from the time of application, or within approximately 1 second from the time of application.

18. A method of sanitizing skin comprising contacting a skin surface with the antimicrobial composition of claim 1.

19. A foaming dispenser comprising the antimicrobial composition of claim 1.

16. An antimicrobial composition comprising:

(a) approximately 0.1 wt. % benzalkonium chloride,

(b) approximately 0.12 wt. % dihydroxypropyl PEG-5 linoleammonium chloride,

(c) approximately 0.1 wt. % glycereth-2 cocoate,

(d) approximately 0.9 wt. % behentrimonium chloride,

(e) approximately 0.06 wt. % dihydroxyethyl cocamine oxide, and

(f) water.

17. An antimicrobial composition comprising:

(a) approximately 0.1 wt. % benzalkonium chloride,

(b) approximately 0.12 w. % dihydroxypropyl PEG-5 linoleammonium chloride,

(c) approximately 0.1 wt. % glycereth-2 cocoate,

(d) approximately 0.9 wt. % behentrimonium chloride,

(e) approximately 0.06 wt. % dihydroxyethyl cocamine oxide,

(f) approximately 0.05 wt. % hydroxypropyl methylcellulose,

(g) approximately 1 wt. % butylenes glycol, and

(h) water.