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Dendrimer-photosensitizer complexes for medical applications

  • US 20060292112A1
  • Filed: 09/01/2006
  • Published: 12/28/2006
  • Est. Priority Date: 08/02/1999
  • Status: Abandoned Application
First Claim
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1. A method of PhotoDynamic Therapy (PDT) at a preselected treatment site, wherein multiple photosensitizers (PS) are applied as dendrimer-photosensitizer complexes using tetrapyrroles as photosensitizers and dendrimers as a multi-functional substrate for said photosensitizers, comprising the steps of:

  • a) attaching a plurality of tetrapyrroles photosensitizers to a dendrimer substrate using a labile bond, wherein said labile bonds are breakable without disrupting bonding within said photosensitizers or within said dendrimer substrate;

    b) introducing said dendrimer-photosensitizer complex to a patient, typically systemically;

    c) allowing time for said dendrimer-photosensitizer complex to preferentially accumulate near a treatment site;

    d) releasing, i.e. breaking one or more labile bonds between said photosensitizer and said dendrimer, said tetrapyrroles photosensitizers from said dendrimer substrate by irradiating with light selected from a group consisting of natural light and artificial light; and

    e) irradiating with a second wavelength light specific to activate said freed photosensitizer to accomplish desired PDT of preselected treatment site.

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