Chondrocyte Therapeutic Delivery System
First Claim
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1. A method for modifying an environment of a cell associated with a disorder using a genetically altered chondrocyte, comprising:
- providing a genetically altered chondrocyte , wherein the genetically altered chondrocyte has been altered to express a therapeutic agent;
delivering the genetically altered chondrocyte to the environment of a cell with a disorder such that the genetically altered chondrocyte does not become structurally functional in the environment surrounding the cell; and
expressing the therapeutic agent to a level sufficient to modify the environment surrounding the cell.
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Abstract
Methods and compositions for producing therapeutic agents using chondrocytes are provided. The genetically engineered chondrocytes can be used to express the therapeutic agent in a subject, including in an environment typically associated with chondrocytes and in an environment not typically associated with chondrocytes.
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Citations
11 Claims
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1. A method for modifying an environment of a cell associated with a disorder using a genetically altered chondrocyte, comprising:
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providing a genetically altered chondrocyte , wherein the genetically altered chondrocyte has been altered to express a therapeutic agent;
delivering the genetically altered chondrocyte to the environment of a cell with a disorder such that the genetically altered chondrocyte does not become structurally functional in the environment surrounding the cell; and
expressing the therapeutic agent to a level sufficient to modify the environment surrounding the cell. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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Specification