Bioadhesive liquid composition which is substantially free of water
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Abstract
A liquid composition for adherence to a bodily surface, notably to a bodily surface, especially a mucosal surface, comprises water-swellable polymer particles suspended in a water-miscible liquid diluent, wherein the liquid diluent is substantially free of water or includes an amount of water insufficient to fully swell the polymer particles. On admixture with water the composition thickens and becomes more adherent to surfaces. Thus the composition may be easy to administer but may become thick and adherent at the treatment site.
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Citations
41 Claims
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1-26. -26. (canceled)
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27. A liquid composition for adherence to a surface, which composition comprises from 20 to 60 wt % water-swellable polymer particles suspended in a water-miscible liquid diluent, wherein
the liquid diluent is free of water or includes an amount of water insufficient to fully swell the polymer particles, the polymer particles do not include both anionic particles and cationic particles, and the composition does not comprise an additional pharmaceutically active agent.
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38. In the manufacture of a liquid pharmaceutical composition for treating or preventing inflammation of or damage to a bodily surface, the improvement which comprises incorporating into said pharmaceutical composition a surface-adhering composition comprising from 20 to 60 wt % of water-swellable polymer particles suspended in a pharmaceutically acceptable water-miscible liquid diluent, the liquid diluent being free of water or containing an amount of water insufficient to fully swell the polymer particles, wherein the polymer particles do not comprise both anionic particles and cationic particles and wherein the adhering composition does not comprise any additional pharmaceutical agent.
- 39. A method of treating a surface comprising applying to the surface a liquid composition comprising water-swellable polymer particles suspended in a water-miscible liquid diluent in which the polymer particles do not comprise both anionic particles and cationic particles and the composition is free of water or includes an amount of water insufficient to fully swell the polymer particles, wherein, prior to application of the composition to the surface or during application of the composition to the surface, water is mixed with the composition to cause swelling of the polymer particles in the vicinity of the surface, an increase in the viscosity of the composition and the formation of an adhered coating of the polymer on the surface.
Specification