Gel compositions for topical administration
First Claim
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1. A pharmaceutical gel composition for topical administration comprising:
- (a) at least one pharmacologically active agent in an amount of about 0.00001% to about 10% by weight of the composition;
(b) at least one hydrogen-bonding gelation polymer; and
(c) at least one gelation promoter in an amount effective to gel the polymer and to at least partially solubilize the pharmacologically active agent, wherein at least a portion of the pharmacologically active agent is dissolved in the composition at 15°
C.
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Abstract
Pharmaceutical gel compositions containing pharmacologically active agent for topical administration, as well as a method of making the same, are disclosed.
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Citations
26 Claims
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1. A pharmaceutical gel composition for topical administration comprising:
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(a) at least one pharmacologically active agent in an amount of about 0.00001% to about 10% by weight of the composition;
(b) at least one hydrogen-bonding gelation polymer; and
(c) at least one gelation promoter in an amount effective to gel the polymer and to at least partially solubilize the pharmacologically active agent, wherein at least a portion of the pharmacologically active agent is dissolved in the composition at 15°
C. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 26)
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- 23. A method of making a pharmaceutical gel composition for topical administration comprising the step of admixing at least one pharmacologically active agent in an amount of about 0.00001% to about 10% by weight of the composition, at least one hydrogen-bonding gelation polymer, and at least one gelation promoter or aqueous solution thereof in an amount effective to at least partially solubilize the pharmacologically active agent and to gel the polymer to form the pharmaceutical gel composition, wherein at least a portion of the pharmacologically active agent is dissolved in the composition at 15°
Specification