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Methods and kits for drug screening and toxicity testing using promoter-reporter cells derived from embryonic stem cells

  • US 20060292695A1
  • Filed: 09/22/2005
  • Published: 12/28/2006
  • Est. Priority Date: 06/22/2005
  • Status: Abandoned Application
First Claim
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1. A method of drug testing, comprising:

  • a) combining the drug with a cell population differentiated from human embryonic stem (hES) cells, comprising cells that have been genetically altered so that a promoter that responds to a metabolic or toxicologic change in the cell controls expression of a reporter gene; and

    then b) determining whether there is a change in expression of the reporter gene.

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