Photocrosslinked hydrogel blend surface coatings
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Abstract
Hydrogel polymer blends including precursors and crosslinked forms of the compositions. The blends provide an improved approach to achieve high quality, uniform coatings with better commercial viability than other approaches including copolymerization. Applications include mass spectral analysis of biomolecular analytes such as proteins. Dextran and acrylamide systems are preferred. Benzophenone groups can be used as photocrosslinking groups. Photoinitiators are not needed. Functionalities which can selectively bind to biomolecular analytes are included.
29 Citations
118 Claims
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1-94. -94. (canceled)
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95. A device that comprises a substrate comprising a surface that is coated with a crosslinked hydrogel polymer blend composition, wherein the composition comprises:
- (i) a plurality of first polysaccharide polymer molecules, and (ii) a plurality of second polysaccharide polymer molecules, wherein the second polymer molecules are different from the first polysaccharide polymer molecules and comprise a selective binding functionality, and wherein (a) the first polysaccharide polymer molecules are photocrosslinked with each other and further photocrosslinked with the second polysaccharide polymer molecules through reacted photoreactive groups, wherein photocrosslinking results from photo-reacting photoreactive groups attached to the first polysaccharide polymer molecules, and (b) wherein the device is a probe for a mass spectrometer.
- View Dependent Claims (96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117)
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118. A device that comprises a substrate comprising a surface that is coated with a crosslinked hydrogel polymer blend composition, wherein the composition comprises:
- (i) a plurality of first polysaccharide polymer molecules, and (ii) a plurality of second polysaccharide polymer molecules, wherein the second polymer molecules are different from the first polysaccharide polymer molecules and comprise a selective binding functionality, and wherein (a) the first polysaccharide polymer molecules are photocrosslinked with each other and further photocrosslinked with the second polysaccharide polymer molecules through reacted benzophenone groups, wherein photocrosslinking results from photo-reacting benzophenone groups attached to the first polysaccharide polymer molecules, and (b) wherein the device is a probe for a mass spectrometer, wherein the hydrogel is substantially free of photoinitiator.
Specification