Fungicidal effect by regulating signal transduction pathways
First Claim
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1. A method of treating a Cryptococcus neoformans infection (or cryptococcosis) in a subject in need thereof, comprising administering an active agent to said subject in a treatment-effective amount;
- wherein said active agent is fludioxonil, an analog thereof, or a pharmaceutically acceptable salt or prodrug thereof.
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Abstract
The present invention concerns methods of treating fungal infections and methods of screening compounds for activity in treating fungal infections. Methods of the invention include using an active compound such as fludioxonil to treat a Cryptococcus neoformans infection. Also included are methods and pharmaceutical compositions useful for treating fungal infections using a Hog1 activator such as fludioxonil and a calcineurin inhibitor in combination.
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14 Claims
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1. A method of treating a Cryptococcus neoformans infection (or cryptococcosis) in a subject in need thereof, comprising administering an active agent to said subject in a treatment-effective amount;
- wherein said active agent is fludioxonil, an analog thereof, or a pharmaceutically acceptable salt or prodrug thereof.
- View Dependent Claims (2)
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3. A pharmaceutical composition useful for treating cryptococcosis comprising an active agent in a pharmaceutically acceptable carrier;
- wherein said active agent is fludioxonil, an analog thereof, or a pharmaceutically acceptable salt or prodrug thereof.
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4. A method of treating a fungal infection in a subject in need thereof, comprising administering said subject, in combination:
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a. a Hog1 activator; and
b. a calcineurin inhibitor. - View Dependent Claims (5, 6, 7, 8)
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9. A pharmaceutical composition useful for treating a fungal infection comprising, in a pharmaceutically acceptable carrier,
a. a Hog1 activator; - and
b. a calcineurin inhibitor. - View Dependent Claims (10, 11)
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12. A method of screening a compound for fungicidal activity, comprising:
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a. contacting a fungal cell containing Hog1 to said compound; and
thenb. detecting activation of Hog1 by said compound, activation of Hog1 indicating fungicidal activity of said compound. - View Dependent Claims (13, 14)
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Specification