Soft tissue implants with improved interfaces

• US 20060293760A1
• Filed: 06/24/2005
• Published: 12/28/2006
• Est. Priority Date: 06/24/2005
• Status: Abandoned Application

• Current Assignee: DePuy Synthes Products LLC (Johnson & Johnson)
• Original Assignee: DePuy Synthes Products LLC (Johnson & Johnson)
• Inventors: DeDeyne, Patrick G.
• Application Number:
  US11/166,793
• Publication Number:
  US 20060293760A1
• Time in Patent Office: Days
• US Class Current: 623/23.76
• CPC Class Codes: A61F 2/08 Muscles; Tendons; Ligaments sutures A61B17/04
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2/32 for the hip
• CPC Class Codes: A61F 2/38 for elbows or knees
• CPC Class Codes: A61F 2/3804 for elbows
• CPC Class Codes: A61F 2/40 for shoulders
• CPC Class Codes: A61F 2/4202 for ankles
• CPC Class Codes: A61F 2/442 Intervertebral or spinal discs, e.g. resilient non-disc-shaped intervertebral inflatable pockets A61F2/441; non-disc-shaped intervertebral fusion implants A61F2/4455
• CPC Class Codes: A61F 2002/0894 Muscles non-implantable A61F2002/5066
• CPC Class Codes: A61F 2002/2817 Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
• CPC Class Codes: A61F 2002/30028 differing in tissue ingrowth capacity, e.g. made from both ingrowth-promoting and ingrowth-preventing parts
• CPC Class Codes: A61F 2002/30062 (bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
• CPC Class Codes: A61F 2002/30766 Scaffolds for cartilage ingrowth and regeneration
• CPC Class Codes: A61F 2002/30971 Laminates, i.e. layered products
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2240/001 Designing or manufacturing processes
• CPC Class Codes: A61F 2250/0051 differing in tissue ingrowth capacity, e.g. made from both ingrowth-promoting and ingrowth-preventing parts
• CPC Class Codes: A61L 27/46 with phosphorus-containing inorganic fillers
• CPC Class Codes: C08L 89/06 derived from leather or skin , e.g. gelatin

Abstract

Specialization of the end(s) or host tissue contact points of biocompatible scaffolds brings a functionality to the scaffold that facilitates the dual function of inducing new tissue formation and facilitating attachment and site-specific tissue formation at the scaffolds'"'"' functionalized points of fixation.

Claims

1. An implant for attaching to host tissue comprising a biocompatible scaffold having at least one end or one point for contacting the host tissue, wherein the end or point of contact further comprises a tissue interface composition that permits host tissue ingrowth between the implant and the host tissue.

2. The implant of claim 1, wherein the scaffold is bioabsorbable or nonbioabsorbable.

3. The implant of claim 1 wherein the scaffold is a synthetic or natural polymer.

4. The implant of claim 1 wherein the scaffold is selected from the group consisting of aliphatic polyesters, poly(amino acids), copy(ether-esters, polyalkylenes oxalates, polyamides, tyrosine derived polycarbonates, poly(iminocarbonates), polyorthoesters, polyoxaesters, polyamidoesters, polyoxaesters containing amine groups, poly(anhydrides), polyphosphaenes, poly(propylene fumarate), polyurethane, poly(ester urethane), poly(ether urethane), and blends and copolymers thereof.

5. The implant of claim 1, wherein the scaffold is selected from the group consisting of collagen, laminin, glycosaminoglycans, elastin, thrombin, fibronectin, starches, poly(amino acid), gelatin, alginate, pectin, fibrin, oxidized cellulose, chitin, chitosan, tropoelastin, hyaluronic acid, silk, ribonucleic acids, deoxyribonucleic acids, polypeptides, proteins, polysaccharides, polynucleotides and combinations thereof.

6. The implant of claim 1, wherein the extracellular matrix selected from the group consisting of small intestine submucosa, stomach, bladder, alimentary, respiratory, genital submucosa, liver basement membrane and combinations thereof.

7. The implant of claim 3, wherein the extracellular matrix is small intestine submucosa.

8. The implant of claim 1, wherein the scaffold is an elastomeric polymer selected from the group consisting of ε

-caprolactone, glycolide, lactide, p-dioxanone, trimethylene carbonate and combinations thereof.

9. The implant of claim 1, wherein the scaffold is a polymeric foam.

10. The implant of claim 1, wherein the tissue interface composition comprises a bioactive agent.

11. The implant of claim 10, wherein the bioactive agent is selected from the group consisting of hydroxyapatite, tricalcium phosphate, ceramic glass, amorphous calcium phosphate, porous ceramic particles or powders, demineralized bone particles or powder, bone morphogenic proteins, recombinant human growth factors, cartilage derived morphogenic proteins and combinations thereof.

12. The implant of claim 11, wherein the bone morphogenic proteins are selected from the group consisting of BMP-2, BMP-4, BMP-6, BMP-7, BMP-12, BMP-13, BMP-14 and combinations thereof.

13. The implant of claim 10, wherein the bioactive agent is rhGDF-5.

14. The implant of claim 1, wherein the tissue interface composition is selected from the group consisting of stem cells, bone marrow cells, fibrocytes, adipocytes, chondrocytes and combinations thereof.

15. The implant of claim 1, wherein the tissue interface composition is selected from the group consisting of stem cells, bone marrow cells, IGF-1, HGF and combinations thereof.

16. The implant of claim 1, wherein the tissue interface composition is selected from the group consisting of recombinant human growth factors, transforming growth factors, growth differentiation factors, bone morphogenic proteins, cartilage-derived morphogenic proteins and combinations thereof.

17. The implant of claim 1, wherein the scaffold further comprises a second end or second contact point for contacting the host tissue.

18. A method of implanting a medical device comprising the steps of:

a) providing a scaffold having at least a first end or first contact point and a second end wherein the first end or contact point further comprises a tissue interface composition that permits tissue ingrowth between the device and the host tissue; and

b) contacting the end or contact point comprising the tissue interface composition with the host tissue.

19. The method of claim 21, wherein the host tissue is bone.

20. The method of claim 18, wherein the scaffold mimics a tendon.

21. The method of claim 18, wherein the scaffold mimics a ligament.

22. The method of claim 18, wherein the scaffold mimics a muscle.

23. The method of claim 18, wherein the scaffold mimics an intervertebral disc.

24. The method of claim 18, wherein the tissue is muscle.

25. The method of claim 18, wherein the scaffold is extracellular matrix.

26. The method of claim 25, wherein the extracellular matrix is SIS.

27. The method of claim 26, wherein the tissue interface composition comprises a bioactive agent.