SYSTEM, METHOD, AND COMPUTER PRODUCT FOR CORRECTION OF FEATURE OVERLAP
First Claim
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1. A method for correcting feature overlap in biological probe array data, comprising:
- (a) receiving a first set of data comprising an intensity value for each of a plurality of features associated with a probe array;
(b) calculating a crosstalk parameter for the first set of data using the intensity values of one or more test features and a plurality of features that neighbor each test feature; and
(c) applying the crosstalk parameter to each intensity value in the first set of data to produce a second set of data.
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Abstract
In one embodiment, a method for correcting feature overlap in biological probe array data is described that comprises (a) receiving a first set of data comprising an intensity value for each of a plurality of features associated with a probe array; (b) calculating a crosstalk parameter for the first set of data using the intensity values of one or more test features and a plurality of features that neighbor each test feature; and (c) applying the crosstalk parameter to each intensity value in the first set of data to produce a second set of data.
13 Citations
33 Claims
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1. A method for correcting feature overlap in biological probe array data, comprising:
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(a) receiving a first set of data comprising an intensity value for each of a plurality of features associated with a probe array;
(b) calculating a crosstalk parameter for the first set of data using the intensity values of one or more test features and a plurality of features that neighbor each test feature; and
(c) applying the crosstalk parameter to each intensity value in the first set of data to produce a second set of data. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A system for correcting feature overlap in biological probe array data, comprising:
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a input manager that receives a first set of data comprising an intensity value for each of a plurality of features associated with a probe array;
a calculator that calculates a crosstalk parameter for the first set of data using the intensity values of one or more test features and a plurality of features that neighbor each test feature; and
an adjuster that applies the crosstalk parameter to each intensity value in the first set of data to produce a second set of data. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A system for correcting feature overlap in biological probe array data, comprising:
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a scanner that acquires a first set of data from a biological probe array; and
a computer comprising executable code stored thereon, wherein the executable code performs a method of;
processing the first set of data to produce a second set of data comprising an intensity value for each of a plurality of features associated with the probe array;
calculating a crosstalk parameter for the second set of data using the intensity values of one or more test features and one or more features that neighbor each test feature; and
applying the crosstalk parameter to each intensity value in the second set of data to produce a third set of data.
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26. A method for correcting feature overlap in biological probe array data, comprising:
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(a) receiving a first set of data comprising an intensity value for each of a plurality of features associated with a probe array, and a crosstalk parameter for the first set of data; and
(c) applying the crosstalk parameter to each intensity value in the first set of data to produce a second set of data. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33)
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Specification