Reflection hologram sensor in contact lens
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Abstract
This invention is generally related to a biocompatible sensor for detecting/measuring an analyte of interest in a body fluid and a method for making the biocompatible sensor. A biocompatible sensor of the invention comprises, consists essentially, or consists of a reflection hologram therein or thereon, wherein the reflection hologram is produced in a crosslinkable and/or polymerizable fluid material. The polymer matrix contains a molecular sensing moiety which interacts or reacts with an analyte of interest to provide an optical signal which is indicative of a change in one or more optical properties of the reflection hologram.
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Citations
93 Claims
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1-66. -66. (canceled)
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67. A method for making a biocompatible sensor containing a reflection hologram, comprising the steps of:
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introducing a crosslinkable and/or polymerizable fluid material into a cavity formed by a mold, wherein the crosslinkable and/or polymerizable fluid material comprise at least a molecular sensing moiety which can interact or react with an analyte of interest to provide an optical signal which is indicative of a change in one or more optical properties of the reflection hologram, wherein the mold has a first mold half defining a first molding surface and a second mold half defining a second molding surface, wherein said first mold half and said second mold half are configured to receive each other such that the cavity is formed between said first molding surface and said second molding surface; and
producing and recording a pattern of interference fringes while polymerizing/crosslinking said crosslinkable and/or polymerizable fluid material in the cavity to form the biocompatible sensor, thereby said pattern is recorded in said biocompatible sensor to form the reflection hologram. - View Dependent Claims (68, 69, 70, 71, 72, 73, 74, 75, 76, 77)
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78. A method of claim for making a biocompatible sensor containing a reflection hologram, comprising:
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providing an article having a first surface and an opposite second surface;
spraying at least one layer of a crosslinkable and/or polymerizable fluid material onto the first surface of the article, using a spraying process selected from the group consisting of an air-assisted atomization and dispensing process, an ultrasonic-assisted atomization and dispensing process, a piezoelectric assisted atomization and dispensing process, an electro-mechanical jet printing process, a piezo-electric jet printing process, a piezo-electric with hydrostatic pressure jet printing process, and a thermal jet printing process, wherein the crosslinkable and/or polymerizable fluid material comprise at least a molecular sensing moiety which can interact or react with an analyte of interest to provide an optical signal which is indicative of a change in one or more optical properties of the reflection hologram;
irradiating said crosslinkable and/or polymerizable fluid material with at least two beams of coherent light, wherein one of the two beams is directed to the crosslinkable and/or polymerizable fluid material whereas the other beam is directed to the crosslinkable and/or polymerizable fluid material through the second surface, wherein the two beams of coherent light form a pattern of interference fringes while polymerizing/crosslinking said crosslinkable and/or polymerizable fluid material to form the biocompatible sensor, thereby said pattern is recorded in said biocompatible sensor to form a reflection hologram. - View Dependent Claims (79, 80, 81, 82, 83, 84)
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85. A method for making a biocompatible sensor containing a reflection hologram, comprising the steps of:
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providing a mold, wherein the mold has a first mold half defining a first molding surface and a second mold half defining a second molding surface, wherein said first mold half and said second mold half are configured to receive each other such that a cavity is formed between said first molding surface and said second molding surface;
applying a coating of a first crosslinkable and/or polymerizable fluid material onto at least one area on the first molding surface, using a process selected from the group consisting of an air-assisted atomization and dispensing process, an ultrasonic-assisted atomization and dispensing process, a piezoelectric assisted atomization and dispensing process, an electro-mechanical jet printing process, a piezo-electric jet printing process, a piezo-electric with hydrostatic pressure jet printing process, and a thermal jet printing process, wherein the first crosslinkable and/or polymerizable fluid material comprise at least a molecular sensing moiety which can interact or react with an analyte of interest to provide an optical signal which is indicative of a change in one or more optical properties of the reflection hologram;
producing and recording a pattern of interference fringes while polymerizing/crosslinking said first crosslinkable and/or polymerizable fluid material in the coating to form a reflection hologram on the first molding surfaces;
introducing a second crosslinkable and/or polymerizable fluid material into the cavity formed by the mold; and
polymerizing/crosslinking the second crosslinkable and/or polymerizable fluid material in the cavity to form the biosensor, wherein the coating having the reflection hologram is transferred from one of the molding surfaces into the biosensor and become an integral part of the biosensor during polymerizing/crosslinking of the second crosslinkable and/or polymerizable fluid material in the cavity. - View Dependent Claims (86, 87, 88, 89, 90, 91, 92, 93)
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Specification