Multifunctional medical articles
First Claim
Patent Images
1. A medical article comprising:
- (a) a body member;
(b) a first biocompatible coating at a first surface portion, the first biocompatible coating comprising polymerization initiator and a first biocompatible agent, the first biocompatible agent including one or more reactive groups, one or more polymerizable groups, or a combination of one or more reactive groups and one or more polymerizable groups; and
(c) a second biocompatible coating at a second surface portion, the second biocompatible coating comprising polymerization initiator and a second biocompatible agent, the second biocompatible agent including one or more reactive groups, one or more polymerizable groups, or a combination of one or more reactive groups and one or more polymerizable groups, wherein the first biocompatible agent and second biocompatible agent are immobilized at respective surface portions and are selected to provide different biocompatible functions when the surface portions are in contact with bodily fluids of a patient.
1 Assignment
0 Petitions
Accused Products
Abstract
The invention provides medical articles that include more than one biocompatibility-promoting function. In one aspect, the invention provides a medical articles that include a polymeric matrix including more than one biocompatible agent, wherein each biocompatible agent is provided at a distinct portion of the medical article surface. Methods of making medical articles, as well as methods of using the same, are also described.
-
Citations
40 Claims
-
1. A medical article comprising:
-
(a) a body member;
(b) a first biocompatible coating at a first surface portion, the first biocompatible coating comprising polymerization initiator and a first biocompatible agent, the first biocompatible agent including one or more reactive groups, one or more polymerizable groups, or a combination of one or more reactive groups and one or more polymerizable groups; and
(c) a second biocompatible coating at a second surface portion, the second biocompatible coating comprising polymerization initiator and a second biocompatible agent, the second biocompatible agent including one or more reactive groups, one or more polymerizable groups, or a combination of one or more reactive groups and one or more polymerizable groups, wherein the first biocompatible agent and second biocompatible agent are immobilized at respective surface portions and are selected to provide different biocompatible functions when the surface portions are in contact with bodily fluids of a patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
-
-
22. A method for providing two or more functional surface portions on a medical article, the method comprising steps of:
-
(a) disposing a first composition at a first surface portion of the medical article, the first composition comprising polymerization initiator and a first biocompatible agent, the first biocompatible agent including one or more reactive groups, one or more polymerizable groups, or a combination of one or more reactive groups and one or more polymerizable groups;
(b) activating the polymerization initiator, reactive groups, or a combination thereof, to form a biocompatible coating layer at the first surface portion;
(c) disposing a second composition at a second surface portion of the medical article, the second composition comprising polymerization initiator and a second biocompatible agent, the second biocompatible agent including one or more reactive groups, one or more polymerizable groups, or a combination of one or more reactive groups and one or more polymerizable groups; and
(d) activating the polymerization initiator, reactive groups, or a combination thereof, to form a biocompatible coating layer at the second surface portion, wherein the first biocompatible agent and the second biocompatible agent are immobilized at respective surface portions and are selected to provide different biocompatible functions when the surface portions are in contact with bodily fluids of a patient. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
-
-
37. A method for providing two or more functional surface portions on a medical article, the method comprising steps of:
-
(a) providing a primed first surface portion on the medical article, the primed first surface portion comprising a polymeric initiator;
(b) disposing a first composition at the primed first surface portion of the medical article, the first composition comprising a first biocompatible agent including one or more reactive groups, one or more polymerizable groups, or a combination of one or more reactive groups and one or more polymerizable groups;
(c) activating the polymerization initiator, reactive groups, or a combination thereof, to form a biocompatible coating layer at the first surface portion;
(d) providing a primed second surface portion on the medical article, the primed second surface portion comprising polymerization initiator;
(e) disposing a second composition at the primed second surface portion of the medical article, the second composition comprising polymerization initiator including one or more reactive groups, one or more polymerizable groups, or a combination of one or more reactive groups and one or more polymerizable groups; and
(f) activating the polymerization initiator, reactive groups, or a combination thereof, to form a biocompatible coating layer at the second surface portion, wherein the first biocompatible agent is different from the second biocompatible agent.
-
-
38. A medical article comprising:
-
(a) a first portion that is fabricated of a first device material; and
(b) a second portion that is fabricated of a second device material, the second device material being more hydrophobic relative to the first device material, wherein a first biocompatible agent is immobilized at a surface of the first portion via a first biocompatible coating, the first biocompatible coating comprising a polymerization initiator and the first biocompatible agent, the first biocompatible agent including one or more reactive groups, one or more polymerizable groups, or a combination of one or more reactive groups and one or more polymerizable groups, wherein a second biocompatible agent is immobilized at a surface of the second portion via a second biocompatible coating, the second biocompatible coating comprising a nonionic initiator and the second biocompatible agent, the second biocompatible agent including one or more reactive groups, one or more polymerizable groups, or a combination of one or more reactive groups and one or more polymerizable groups, and wherein the first biocompatible agent is different from the second biocompatible agent.
-
-
39. A method of making a medical article comprising steps of:
-
(a) providing a medical article that includes a first portion that is fabricated of a first device material and a second portion that is fabricated of a second device material, the second device material being more hydrophobic relative to the first device material;
(b) disposing a first biocompatible coating on a surface of the first portion, the first biocompatible coating comprising polymerization initiator and a first biocompatible agent, the first biocompatible agent including one or more reactive groups, one or more polymerizable groups, or a combination of one or more reactive groups and one or more polymerizable groups;
(c) activating the polymerization initiator, reactive groups, or a combination thereof, to form a biocompatible coating layer at the surface of the first portion;
(d) disposing a second biocompatible coating on a surface of the second portion, the second biocompatible coating comprising nonionic initiator and a second biocompatible agent, the second biocompatible agent including one or more reactive groups, one or more polymerizable groups, or a combination of one or more reactive groups and one or more polymerizable groups; and
(e) activating the polymerization initiator, reactive groups, or a combination thereof, to form a biocompatible coating layer at the surface of the second portion, wherein the first biocompatible agent is different from the second biocompatible agent.
-
-
40. A medical article comprising:
-
(a) a body member;
(b) a first coating layer along a length of the body member, the first coating layer comprising a hydrophilic polymer; and
(c) a biocompatible coating in contact with a portion of the first coating layer, the biocompatible coating comprising a biocompatible agent, the biocompatible agent including one or more reactive groups, one or more polymerizable groups, or a combination of one or more reactive groups and one or more polymerizable groups, wherein the biocompatible coating is in contact with a distinct portion of the first coating layer, the distinct portion comprising less than 100% of the first coating layer, and wherein the hydrophilic polymer is selected from poly(vinylpyrrolidone), poly(ethylene glycol), poly(ethylene oxide), poly(ethyloxazoline), poly(propylene oxide), polyacrylamide, poly(vinyl alcohol), and copolymers or combinations of any of these.
-
Specification