Semi-permeable compositions providing reduced drying time for osmotic dosage forms

• US 20070003624A1
• Filed: 06/29/2006
• Published: 01/04/2007
• Est. Priority Date: 06/29/2005
• Status: Abandoned Application

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Barclay, Brian, Shanbhag, Anant
• Application Number:
  US11/478,221
• Publication Number:
  US 20070003624A1
• Time in Patent Office: Days
• US Class Current: 424/473
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61K 9/2086 Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat active cores with a complete drug-free outer coat A61K9/28
• CPC Class Codes: A61K 9/2866 Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Abstract

Disclosed are methods including providing an osmotic core; coating the osmotic core with a coating composition that comprises cellulose acetate butyrate; drying the coated osmotic core for a maximum period of about 36 hours; wherein the coated core is dried to an average residual solvent content of less than about 1000 parts per million. Also disclosed are coated osmotic cores and methods of administering the coated osmotic cores to a patient.

Claims

1. A method comprising:

providing an osmotic core;

coating the osmotic core with a coating composition that comprises cellulose acetate butyrate;

drying the coated osmotic core for a maximum period of about 36 hours;

wherein the coated core is dried to an average residual solvent content of less than about 1000 parts per million.

2. The method of claim 1, wherein the coating composition further comprises from about 0.01% to about 40% by weight or more of a flux regulator, based on total solids in the coating composition.

3. The method of claim 2, wherein the coating composition further comprises from about 10 wt % to about 30 wt % of a flux regulator, based on total solids in the coating composition.

4. The method of claim 1, wherein the coated osmotic core is dried for a maximum period of about 24 hours;

5. The method of claim 1, wherein the coated core is dried to an average residual solvent content of less than about 500 parts per million.

6. The method of claim 1, wherein the osmotic core comprises a trilayer osmotic core.

7. A dosage form comprising the coated osmotic core of claim 1

8. A method comprising:

providing an osmotic core;

coating the osmotic core with cellulose acetate butyrate;

drying the coated osmotic core for a maximum period of about 24 hours;

administering the coated osmotic core to a patient;

wherein the coated core is dried to an average residual solvent content of less than about 1000 parts per million.

9. The method of claim 8, wherein the coating composition further comprises from about 0.01% to about 40% by weight or more of a flux regulator, based on total solids in the coating composition.

10. The method of claim 9, wherein the coating composition further comprises from about 10 wt % to about 30 wt % of a flux regulator, based on total solids in the coating composition.

11. The method of claim 8, wherein the coated osmotic core is dried for a maximum period of about 24 hours;

12. The method of claim 8, wherein the coated core is dried to an average residual solvent content of less than about 500 parts per million.

13. The method of claim 8, wherein the osmotic core comprises a trilayer osmotic core.

14. The method of claim 8, wherein the osmotic core comprises an osmagent.

15. The method of claim 8, wherein the coated osmotic core is orally administered to a patient.