Multiplexed biological analyzer planar array apparatus and methods
First Claim
1. A planar array comprising a plurality of biological recognition molecules including at least two types of biological recognition molecules distributed about a substrate wherein a first type of biological recognition molecules is distributed according to a first frequency and a second type of biological recognition molecules is distributed according to a second frequency.
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Abstract
A planar array having plurality of biological recognition molecules including at least two types of biological recognition molecules distributed about a substrate is disclosed. A first type of biological recognition molecules is distributed according to a first frequency and a second type of biological recognition molecules is distributed according to a second frequency. Another planar array having a plurality of biological recognition molecules including at least two kinds of biological recognition molecules is disclosed. The recognition molecules are distributed about a substrate with first kind of biological recognition molecules distributed at a first height or depth relative to a surface of the substrate and a second kind of biological recognition molecules distributed at a second height or depth relative to the surface. An apparatus including a surface normal interferometry platform including a scanning pathway and a plurality of analyzer molecules adapted to detect the presence or absence of a plurality of target analytes is also disclosed. The plurality of analyzer molecules are distributed about the scanning pathway according to a multiplexing scheme. A method including multiplexing a plurality of kinds of capture molecules about a detection pathway is further disclosed. The method also includes contacting a biological sample to the array, detecting the presence or absence of binding of the plurality of kinds of capture molecules and a plurality of target analytes using interferometry.
110 Citations
20 Claims
- 1. A planar array comprising a plurality of biological recognition molecules including at least two types of biological recognition molecules distributed about a substrate wherein a first type of biological recognition molecules is distributed according to a first frequency and a second type of biological recognition molecules is distributed according to a second frequency.
- 5. A planar array comprising a plurality of biological recognition molecules including at least two kinds of biological recognition molecules distributed about a substrate wherein a first kind of biological recognition molecules is distributed at a first height or depth relative to a surface of the substrate and a second kind of biological recognition molecules is distributed at a second height or depth relative to the surface.
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8. An apparatus comprising:
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a surface-normal interferometry platform including a scanning pathway; and
a plurality of analyzer molecules adapted to detect the presence or absence of a plurality of target analytes, the plurality of analyzer molecules distributed about the scanning pathway according to a multiplexing scheme. - View Dependent Claims (9, 10, 11, 12, 13)
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14. A method comprising:
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multiplexing a plurality of kinds of capture molecules about a detection pathway;
contacting a biological sample to the array;
detecting the presence or absence of binding of the plurality of kinds of capture molecules and a plurality of target analytes using interferometry. - View Dependent Claims (15, 16, 17, 18, 19, 20)
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Specification