Methods for selecting medications
First Claim
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1. A method for selecting a psychotropic medication for a patient, said method comprising (a) providing said patient'"'"'s genotype for a panel of genes, wherein said panel comprises at least three cytochrome P450 genes and a serotonin transporter gene;
- and (b) selecting said psychotropic medication based on said genotype.
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Abstract
Methods for selecting a medication for a patient are described that include determining the patient'"'"'s genotype for a panel of genes and selecting the medication based on the genotype. Articles of manufacture also are provided that include nucleic acid molecules for detecting alleles of genes encoding drug metabolizing enzymes and genes encoding products involved in neurotransmission.
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Citations
47 Claims
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1. A method for selecting a psychotropic medication for a patient, said method comprising
(a) providing said patient'"'"'s genotype for a panel of genes, wherein said panel comprises at least three cytochrome P450 genes and a serotonin transporter gene; - and
(b) selecting said psychotropic medication based on said genotype. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. An article of manufacture comprising a substrate, said substrate comprising a plurality of discrete regions, wherein each said region comprises a different population of nucleic acid molecules, wherein said different populations of nucleic acid molecules independently comprise nucleic acid molecules for detecting the CYP1A2*1A and 1A2*3 alleles;
- the CYP2C19*1A, 2C19*1B, and 2C19*2A alleles;
the CYP2D6*1A, 2D6*2, 2D6*2N, 2D6*3, 2D6*4, 2D6*5, 2D6*6, 2D6*7, 2D6*8, 2D6*10, 2D6*12, 2D6*17, and 2D6*35 alleles;
the CYP3A4*1A and 3A4*1B alleles;
the serotonin receptor 2A C/T, T/T, C/C alleles; and
the 5HTT promoter repeat and exon 2 variable repeat alleles. - View Dependent Claims (28, 29, 30, 31)
- the CYP2C19*1A, 2C19*1B, and 2C19*2A alleles;
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32. A method of building a database for use in selecting a medication for a patient, said method comprising:
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(a) receiving, in a computer system, a plurality of genotypes for a panel of genes;
(b) receiving a plurality of medication profiles specified based on the genotypes; and
(c) storing said plurality of genotypes and the medication profiles such that each medication profile is associated with one of the genotypes. - View Dependent Claims (33, 34, 35, 36)
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37. A computer program product containing executable instructions that when executed cause a processor to perform operations comprising:
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(a) receive a plurality of genotypes for a panel of genes;
(b) receive a plurality of medication profiles specified based on the genotypes; and
(c) store the genotypes and the medication profiles such that each medication profile is associated with one of the genotypes.
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38. A method of selecting a medication for a patient, the method comprising:
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(a) receiving, in a computer system, a patient'"'"'s genotype for a panel of genes;
(b) identifying, in a database comprising a plurality of medication profiles associated with genotypes, a medication profile that is associated with the patient'"'"'s genotype; and
(c) outputting the identified medication profile in response to receiving the patient'"'"'s genotype. - View Dependent Claims (39, 40, 41, 42, 43, 44, 45, 46)
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47. A computer program product containing executable instructions that when executed cause a processor to perform operations comprising:
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(a) receive a patient'"'"'s genotype for a panel of genes;
(b) identify, in a database including a plurality of medication profiles associated with genotypes, a medication profile that is associated with the patient'"'"'s genotype; and
(c) output the identified medication profile in response to receiving the patient'"'"'s genotype.
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Specification