Tendon-inducing compositions

• US 20070004005A1
• Filed: 06/17/2005
• Published: 01/04/2007
• Est. Priority Date: 12/07/1993
• Status: Active Grant

• Current Assignee: President and Fellows of Harvard College (Harvard Corporation), Genetics Institute LLC (Pfizer Inc.)
• Original Assignee: President and Fellows of Harvard College (Harvard Corporation), Genetics Institute LLC (Pfizer Inc.)
• Inventors: Wolfman, Neil, Wozney, John, Celeste, Anthony, Melton, Douglas, Rosen, Vicki, Thomsen, Gerald
• Granted Patent: US 7,365,052 B2
• Time in Patent Office: Days
• US Class Current: 435/69.100
• CPC Class Codes: A61K 38/1875 Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
• CPC Class Codes: A61L 27/227 Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
• CPC Class Codes: A61L 27/386 Ligaments, tendons
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 19/04 for non-specific disorders of the connective tissue
• CPC Class Codes: A61P 19/08 for bone diseases, e.g. rachitism, Paget's disease
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 5/00 Drugs for disorders of the endocrine system
• CPC Class Codes: C07K 14/51 Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
• CPC Class Codes: C07K 2319/02 containing a signal sequence

Abstract

Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related tissue repair.

Claims

1-28. -28. (canceled)

29. A method for regenerating a functional attachment between tendon and/or ligament tissue and bone comprising administering an effective amount of a protein selected from the group consisting of BMP-12, BMP-13, and MP-52 to a patient in need of same.

30. The method of claim 29, wherein the protein administered is BMP-12.

31. The method of claim 29, wherein the protein administered is BMP-13.

32. The method of claim 29, wherein the protein administered is MP-52.

33. A method for treating a tendon and/or ligament defect comprising administering an effective amount of a protein selected from the group consisting of BMP-12, BMP-13, and MP-52 to a patient in need of same.

34. The method of claim 33, wherein the protein administered is BMP-12.

35. The method of claim 33, wherein the protein administered is BMP-13.

36. The method of claim 33, wherein the protein administered is MP-52.