Flow cell device, sensor unit and assay apparatus
First Claim
1. A flow cell device comprising:
- a flow cell body, having a lower surface, and disposed in contact of said lower surface with a sensing surface for detecting reaction of sample;
at least two flow channels, formed in said flow cell body, for flow of said sample;
each of said flow channels including a fluid passageway, formed in said lower surface, for flow of said sample in contact with said sensing surface, and two end cavities, formed in an upper surface of said flow cell body and open therein, to extend from ends of said fluid passageway;
at least one flow channel set for constituting said at least two flow channels, said flow channels being arranged adjacent to one another as viewed in a direction of said flow, disposed to extend in said direction of said flow, fluid passageways of said flow channels being overlapped partially on one another in a predetermined direction of said flow cell body.
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Accused Products
Abstract
A flow cell device is incorporated in the sensor unit for surface plasmon resonance (SPR) assay. A box shaped flow cell body has a lower surface, and is disposed in contact of the lower surface with a sensing surface for detecting reaction of sample. Two flow channels are formed in the flow cell body, for flow of the sample. Each of the flow channels include a fluid passageway, formed in the lower surface, for flow of the sample in contact with the sensing surface. Two end cavities are formed in an upper surface of the flow cell body and open therein, to extend from ends of the fluid passageway. The flow channels are arranged adjacent to one another, disposed to extend in a direction of the flow. Fluid passageways of the flow channels are overlapped partially on one another in a flow cell longitudinal direction of the flow cell body.
26 Citations
20 Claims
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1. A flow cell device comprising:
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a flow cell body, having a lower surface, and disposed in contact of said lower surface with a sensing surface for detecting reaction of sample;
at least two flow channels, formed in said flow cell body, for flow of said sample;
each of said flow channels including a fluid passageway, formed in said lower surface, for flow of said sample in contact with said sensing surface, and two end cavities, formed in an upper surface of said flow cell body and open therein, to extend from ends of said fluid passageway;
at least one flow channel set for constituting said at least two flow channels, said flow channels being arranged adjacent to one another as viewed in a direction of said flow, disposed to extend in said direction of said flow, fluid passageways of said flow channels being overlapped partially on one another in a predetermined direction of said flow cell body. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A sensor unit, having a dielectric medium overlaid with a thin film for attenuating reflected illuminating light upon application of said illuminating light to satisfy a total reflection condition, and at least one flow cell device disposed to contact said dielectric medium, for causing sample to flow to a sensing surface on said thin film, wherein when said sample contacts said sensing surface, an incidence angle of said illuminating light of occurrence of attenuation is changed according to reaction of said sample, said sensor unit comprising:
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said flow cell device including;
a flow cell body, having a lower surface, and disposed in contact of said lower surface with said sensing surface;
at least two flow channels, formed in said flow cell body, for flow of said sample;
each of said flow channels including a fluid passageway, formed in said lower surface, for flow of said sample in contact with said sensing surface, and two end cavities, formed in an upper surface of said flow cell body and open therein, to extend from ends of said fluid passageway;
said flow cell device including at least one flow channel set for constituting said at least two flow channels, said flow channels being arranged adjacent to one another as viewed in a direction of said flow, disposed to extend in said direction of said flow, fluid passageways of said flow channels being overlapped partially on one another in a predetermined direction of said flow cell body. - View Dependent Claims (16, 17)
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18. An assay apparatus for assay in utilizing attenuated total reflection, including an assay stage for supporting a sensor unit removably, a light source for applying illuminating light to a thin film of said sensor unit to satisfy a total reflection condition, and a photo detector for receiving said illuminating light reflected by said thin film and for conversion into an electric signal, said assay apparatus comprising:
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said sensor unit having a dielectric medium overlaid with said thin film for attenuating reflected illuminating light upon application of said illuminating light to satisfy a total reflection condition, and at least one flow cell device disposed to contact said dielectric medium, for causing sample to flow to a sensing surface on said thin film, wherein when said sample contacts said sensing surface, an incidence angle of said illuminating light of occurrence of attenuation is changed according to reaction of said sample;
said flow cell device including;
a flow cell body, having a lower surface, and disposed in contact of said lower surface with said sensing surface;
at least two flow channels, formed in said flow cell body, for flow of said sample;
each of said flow channels including a fluid passageway, formed in said lower surface, for flow of said sample in contact with said sensing surface, and two end cavities, formed in an upper surface of said flow cell body and open therein, to extend from ends of said fluid passageway;
said flow cell device including at least one flow channel set for constituting said at least two flow channels, said flow channels being arranged adjacent to one another as viewed in a direction of said flow, disposed to extend in said direction of said flow, fluid passageways of said flow channels being overlapped partially on one another in a predetermined direction of said flow cell body. - View Dependent Claims (19, 20)
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Specification