Gene therapy methods and cell growth and cell transplant devices for use therein
First Claim
Patent Images
1. An artificial connective tissue, comprising:
- a plurality of elongated fibers each having a first end and a second end;
a first end fiber at said first end of said elongated fibers; and
a second end fiber at said second end of said elongated fibers, wherein said first and said second end fibers connect said respective first and second ends of said elongated fibers.
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Abstract
An artificial tendon, ligament, bone and skin panel are provided, made of biocompatible materials and capable of being seeded and eventually coated with selected cell types. Seeded or coated artificial tendon, ligament, bone or skin panels can be shaped and implanted in mammals. Implantable cell growth cages may be seeded with selected cell types and used to produce desired gene expression products within a mammal. Gene expression products may be harvested from transfected animal cells cultured in a cell growth chamber.
17 Citations
22 Claims
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1. An artificial connective tissue, comprising:
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a plurality of elongated fibers each having a first end and a second end;
a first end fiber at said first end of said elongated fibers; and
a second end fiber at said second end of said elongated fibers, wherein said first and said second end fibers connect said respective first and second ends of said elongated fibers. - View Dependent Claims (2, 3)
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4. An artificial weight-bearing bone, comprising:
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a plurality of elongated members;
a plurality of circular fibers; and
at least one layer of bone or cartilage cells on at least one of said elongated members, wherein said elongated members form a generally cylindrical structure, wherein said circular fibers are located around and permanently attached to said elongated members, and wherein said circular fibers are spaced along the length of said elongated members. - View Dependent Claims (5, 6, 7)
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8. An artificial weight-bearing bone, comprising:
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a plurality of elongated members;
a plurality of circular fibers; and
at least one layer of bone or cartilage cells on at least one of said elongated members, wherein said elongated members form a structure that mimics the shape of a natural bone or portion thereof, and wherein each of said circular fibers are located around and permanently attached to at least two of said elongated members. - View Dependent Claims (9, 10)
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11. An artificial non weight-bearing bone, comprising:
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at least one artificial bone scaffold; and
at least one layer of bone or cartilage cells on said artificial bone scaffold, wherein said artificial bone scaffold is configured to mimic the shape of a natural bone or a portion thereof. - View Dependent Claims (12, 13)
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14. An artificial skin panel, comprising:
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a fibrous matrix; and
at least one cellular coating on said fibrous matrix, wherein said at least one cellular coating is comprised of cells selected from the group consisting of superficial cutaneous cells and deep cutaneous cells.
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15. An artificial cell growth cage, comprising:
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a fibrous matrix; and
a plurality of cells on and within said fibrous matrix, wherein said cells are capable of producing a desired gene expression product. - View Dependent Claims (16, 17, 18, 19)
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20. A cellular growth chamber, comprising:
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a vessel;
an opening in said vessel that allows insertion and removal of a plurality of porous inner tubes and that is sealingly closeable; and
a sealable port providing a opening in said vessel and allowing inlet and outlet of cell culture solution. - View Dependent Claims (21, 22)
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Specification